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Products

(α)-Synuclein

Cat. No.
CSR-SYN04-COS
Quantity
0.1MG
Price
¥ 36,000
$ 480
€ 360
Inventory
Available
Immunogen
Human
Immunogen detail
Recombinant E.coli
Other
[Background]
In spite of bacterially expressed human alpha-synuclein ( α -syn) has been widely used in structural and
functional studies, approximately 20% of human α -syn expressed in Escherichia coli is mistranslated and
that a Cys residue is incorporated at position 136 instead of a Tyr¹. This mutagenesis of codon resulted the
levels of dimeric α -syn were increased by misincorporation¹.
To avoid these potential artefacts, this product is codon-optimized recombinant protein, and can be used as
human α -syn under much similar condition to that of in vivo.
This product can also be used for a comparison (control) of α -Synuclein Fibrils (CSR-SYN03-COS).
Storage
-20C
Reference
・FEBS Lett. 2006 Mar 20;580(7):1775-9. Cysteine misincorporation in bacterially expressed human alpha-synuclein.
 Masuda M, Dohmae N, Nonaka T, Oikawa T, Hisanaga S, Goedert M, Hasegawa M. PMID: 16513114