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(α)-Synuclein Fibrils

Cat. No.
CSR-SYN03-COS
Quantity
0.1MG
Price
¥ 120,000
$ 1600
€ 1200
Inventory
Available
Other
[Background]
Dementia is a disease that causes memory and judgement loss, there is no fundamental treatment developed for
it. Years of scientifi c research has proven that protein aggregation occurs in the degeneration part of the brain for
many neurodegenerative diseases including dementia, indicating appearance of this aggregation is closely related
to these diseases development and progression.
 Aggregation occurs when normal protein forms abnormal structure for particular reasons and accumulates in
the cell, which each disease has diff erent aggregating protein. It is known that protein called “ α -Synuclein“ forms
abnormal structure in Parkinson Disease / Lewy Body Dementia / Multiple system atrophy patient brain.
Storage
4C DNF
Reference
・Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.
 Yonetani M, Nonaka T, Masuda M, Inukai Y, Oikawa T, Hisanaga S, Hasegawa M.
J Biol Chem. 2009 Mar 20;284(12):7940-50 (PMID: 19164293)
・Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.
Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M.
J Biol Chem. 2010 Nov 5;285(45):34885-98 (PMID: 20805224)
・Prion-like spreading of pathological α -synuclein in brain.
Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann DM, Hasegawa M.
Brain. 2013 Apr;136(Pt 4):1128-38 (PMID: 23466394)