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(α)-Synuclein Aggregation Assay Kit

(ALPHA)-Synuclein Aggregation Assay Kit
Cat. No.
CSR-SYN01-COS
Quantity
1KIT
(300 test)
Price
¥ 110,400
$ 1472
€ 1104
Inventory
Available
Composition
・pCMV-SNCA ( α - Synuclein Expression plasmid vector,Red cap)
・pCMV-NC(Negative control vector, Green cap)
・pCMV-dGFP(dGFP Expression plasmid vector,Blue cap)
・20 mM Tris-HCl Buffer(pH7.4)
・F- α Syn ( α - Synuclein Fibrils, Yellow cap)
・Multifectam (Gene transfection reagent)
Other
[Background]
Dementia is a disease that causes memory and judgement loss, there is no fundamental treatment developed for it.
Years of scientific research has proven that protein aggregation occurs in the degeneration part of the brain for many
neurodegenerative diseases including dementia, indicating appearance of this aggregation is closely related to these diseases
development and progression.
Aggregation occurs when normal protein forms abnormal structure for particular reasons and accumulates in the cell, which
each disease has diff erent aggregating protein. It is known that protein called “ α -Synuclein“ forms abnormal structure in
Parkinson Disease / Lewy Body Dementia / Multiple system atrophy patient brain.
α -Synuclein Aggregation Assay Kit mimics intracellular aggregation of “ α -Synuclein“, which allows in vitro screening of
active ingredients. 
Storage
4C DNF
(ALPHA)-Synuclein Aggregation Assay Kit
(ALPHA)-Synuclein Aggregation Assay Kit
(ALPHA)-Synuclein Aggregation Assay Kit
(ALPHA)-Synuclein Aggregation Assay Kit
(ALPHA)-Synuclein Aggregation Assay Kit
Figure Explain:
IMG1. Product Image
IMG2. Preperation of pCMV-SNCA / F- α Syn / MultiFectam(For 1 well of 24-well plate size
IMG3. Vector map
IMG4. Experimental example of detecting synuclein aggregation complex by western blotting
IMG5. Example of detection using Amyloid Structure Fluorescent Staining Kit
Reference
J Biol Chem. 2010 Nov 5;285(45):34885-98. doi: 10.1074/jbc.M110.148460. Epub 2010 Aug 30.
Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.
Nonaka T, Watanabe ST, Iwatsubo T, Hasegawa M.
PMID : 20805224