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Products

Anti (α) Synuclein (31-40) antibody

Cat. No.
CAC-TIP-SN-P04
Quantity
50UL
Price
¥ 32,000¥ 40,000
$ 534
€ 400
Inventory
Available
Antigen/Source
α Synuclein (31-40)
Host
Rabbit
Reacts with
Human
Immunogen detail
[[epitope]]GKTKEGVLYVC (αsyn31-40)
Isotype
IgG
Fraction
Serum
Applications
Immunohistochemistry/Western Blot
Other
[Background]
Alpha-Synuclein, a 140-amino acid protein abundantly expressed in presynaptic terminals, is known as a component of
intraneuronal or glial inclusions observed in cases of Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and
Multiple system atrophy (MSA). Alpha-Synuclein is a natively unfolded protein, however, fibrillization or conformational
change of Alpha-synuclein is central in the pathogenesis of Alpha-synucleinopathies. The amino-terminal region of
Alpha-synuclein consists of seven imperfect repeats, each 11 amino acids in length, with the consensus sequence
KTKEGV. The repeats partially overlap with a hydrophobic region (amino acids 61-95). The carboxy-terminal region
(amino acids 96-140) is negatively charged. These antibodies are powerful tools for biochemical and IHC analyses of
neurodegenerative diseases and for evaluation of conformational changes of Alpha-synuclein.
Storage
-20C
Reference


Bibliography


  • (1)Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.
    Masuda M, Hasegawa M, Nonaka T, Oikawa T, Yonetani M, Yamaguchi Y, Kato K, Hisanaga S, Goedert M.
    FEBS Lett. 2009 Feb 18;583(4):787-91. doi: 10.1016/j.febslet.2009.01.037. Epub 2009 Feb 4. PMID: 19183551