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Products

Anti CD44v10-e16 antibody

Anti CD44v10-e16
Cat. No.
CAC-LKG-M002
Quantity
100UG
Price
¥ 100,000
$ 1334
€ 1000
Inventory
Available
Antigen/Source
CD44 v10-e16
Host
Rat
Immunogen
Mouse
Reacts with
Mouse
Immunogen detail
Mouse CD44 v8-10 transfected cell
Clone
RM1
Isotype
IgG2a
Conjugation
Unlabeled
Fraction
Ig fraction - Protein G
Applications
Flow Cytometry
note: Other applications have not been tested. Optimal dilutions/concentrations should be determined by the end user. Detailed procedure is provided in the following PROTOCOLS.
Reactivity
Specificity: Mouse CD44 v10-e16
Other
[Background]
CD44 is a single-pass type I transmembrane protein and functions as a cellular adhesion molecule for hyaluronic acid, a major component of the extracellular matrix. CD44 exists in numerous isoforms generated through mRNA splicing. Whereas the standard isoform of CD44 (CD44 s) is expressed predominantly in hematopoietic cells and normal epithelial cell subsets, CD44v (variant) isoforms contain insertions in the membrane-proximal extracellular region and are highly expressed in epithelial-type carcinomas. Moreover, CD44 is reported as cell surface marker for cancer stem cells (CSCs) derived from solid tumors including breast, prostate, colon, head and neck and pancreatic cancer. Expression of CD44, especially variant isoforms (CD44 v8-10), also contribute to reactive oxygen species (ROS) defense by playing a role in controlling glutathione (GSH) synthesis, the primary intracellular antioxidant. CD44 v8-10 interacts with and stabilizes xCT, a subunit of the cystine-glutamate transporter xc(-), and thereby promotes cystine uptake to enhance GSH synthesis. The ability to avoid the consequences of exposure to high levels of ROS is required for cancer cell survival and propagation in vivo. Thus, enhanced resistance to ROS is thought to be an important contributing factor to CSC survival, and a driver of tumor growth, metastasis, and chemoresistance.
Storage
4C
Anti CD44v10-e16
Reference
Reference Page