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Products

Anti CD44v9 antibodyCD44 variant isoform 9

Anti CD44v9
Cat. No.
CAC-LKG-M001
Quantity
100UG
Price
¥ 100,000
$ 1334
€ 1000
Inventory
Available
Antigen/Source
CD44 v9
Host
Rat
Immunogen
Human
Reacts with
Human
Immunogen detail
Human CD44 v8-10 transfected cell
Clone
RV3
Isotype
IgG2a
Conjugation
Unlabeled
Fraction
Ig fraction - Protein G
Applications
Western Blot/IHC paraffin embedding section/Immuno Fluorescence/Enzyme Linked Immunosorbent Assay/Flow Cytometry/Immunoprecipitation
Reactivity
Specificity: Human CD44 v9
Other
[Background]
CD44 is a single-pass type I transmembrane protein and functions as a cellular adhesion molecule for hyaluronic acid, a major component of the extracellular matrix. CD44 exists in numerous isoforms generated through mRNA splicing. Whereas the standard isoform of CD44 (CD44 s) is expressed predominantly in hematopoietic cells and normal epithelial cell subsets, CD44v (variant) isoforms contain insertions in the membrane-proximal extracellular region and are highly expressed in epithelial-type carcinomas. Moreover, CD44 is reported as cell surface marker for cancer stem cells (CSCs) derived from solid tumors including breast, prostate, colon, head and neck and pancreatic cancer. Expression of CD44, especially variant isoforms (CD44 v8-10), also contribute to reactive oxygen species (ROS) defense by playing a role in controlling glutathione (GSH) synthesis, the primary intracellular antioxidant. CD44 v8-10 interacts with and stabilizes xCT, a subunit of the cystine-glutamate transporter xc(-), and thereby promotes cystine uptake to enhance GSH synthesis. The ability to avoid the consequences of exposure to high levels of ROS is required for cancer cell survival and propagation in vivo. Thus, enhanced resistance to ROS is thought to be an important contributing factor to CSC survival, and a driver of tumor growth, metastasis, and chemoresistance.
Storage
4C
Anti CD44v9
Anti CD44v9
Anti CD44v9
Anti CD44v9
Reference
Reference Page