Immunofluorescence: Mouse Cerebal Cortex Tissue
Immunofluorecence: TP deficient Mouse Cerebal Cortex Tissue
These figures were provided by T. Mitsumori in Narumiya's lab.
Function: Receptor for thromboxaneA2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a Gprotein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Namba T, et al. Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992 May 15;184(3):1197-203.
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.