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Anti NOD1 antibody

Background

A cytosolic surveillance system mediated by the nucleotide-binding oligomerization domain (NOD) proteins plays an important role in recognizing intracellular microbe-associated molecular patterns (MAMPs). It has been found that meso-diaminopimelic acid (meso-DAP)-containing peptide moieties, such as γ-D-glutamyl-meso-DAP (iE-DAP) are recognized by NOD1. Porcine NOD1 is more closely related to the human protein than the mouse counterpart and that it is expressed not only in the cytoplasm but also on the inner side of the plasma membrane in the transfected cells. This antibody is useful for biochemical and immunohistochemical analyzes of porcine NOD1 and for clarifying how the immune system is modulated by low-molecular weight peptidoglycan fragments through NOD1.

Specification

Host Rabbit
Specificity Porcine NOD1
Antigen Amino acids 404-416 of porcine NOD1
Cross reactivity Reacts with porcine. Not yet tested in other species.
Applications IHC, FC, WB (Other applications have not been tested.)

Example Assay Data

Immunofluorescence staining



Immunofluorescence staining of NOD1 in Porcine NOD1-expressing HEK293 cells
with anti Porcine NOD1 antibody. [ Green: NOD1, Red: Nuclei ] Ref.1)


Product List

Product Name Cat# Quantity Price

Anti NOD1

CAC-THU-A-NOD1 50UL

¥ 30,000
$ 400
€ 300

References
  • Tohno M, Shimazu T, Aso H, Uehara A, Takada H, Kawasaki A, Fujimoto Y, Fukase K, Saito T, Kitazawa H.,
    Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine.
    Mol Immunol. 2008 Mar;45(6):1807-17. PMID: 17983657

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.