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High-quality antibody necessary for transcriptional control signal

Anti human HNF4 alpha mouse monoclonal antibody (isoforms1,2,4,5,7and 8)

HNF4 alpha : Hepatocyte Nuclear Factor 4 alpha

Background

Hepatocyte nuclear factor 4 alpha (HNF4, HNF4a ; NR2A1) is a member of orphan nuclear receptor. HNF4a is expressed in the liver, kidney, intestine andpancreas. Mutation of HNF4a in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4a gene is alternatively spliced and may generate up to nine different isoforms, HNF4a1 through HNF4a9.

Application

<Recommended Concentration>
In order to obtain the best results, optimal working dilutions should be determined by each individual user.
Western Blot : 1 ug/mL
ELISA : 0.1 ug / mL
Immunoprecipitation : Decide by use
Supershift Assay : Not yet tested
Chromatin immunoprecipitation : Not yet tested
Immunohistochemistry : 10-20 ug / mL


Human Liver Hepatocyte paraffin section


Rat Intestine Epithelial cell paraffin section

<Reference>
1. Jae Mi Suh, et al. Mol Endocrinol, Dec. 2006, 20(12):3412-3420
2. Jun Qin, et al. Developmemtal Dynamics, 2007, 236:810-820 Higashiyama, et al. Acta Histochem, 2007, [E pub]

Specificity

This antibody specifically recognizes human HNF4 alpha 1- 6 and cross reacts with mouse and rat HNF4 alpha 1-6.

Product List

Product Name Cat# Quantity Price

Anti HNF4(ALPHA) (isoforms1,2,4,5,7and 8)

PPX-PP-H1415-00 0.1ML

¥ 50,000
$ 667
€ 500