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Pentraxin 3 (PTX3) appears to be an excellent predicative biomarker for acute coronary syndrome

Human Pentraxin3 / TSG-14 ELISA System

Immunosorbent assay for the quantitative measurement of human Pentraxin3(PTX3) in plasma and serum-free cell culture supernatant

PPX_PPPPZ122800_1.jpg

Background

Inflammatory mediators are closely involved in atherosclerosis, plaque formation and rapture1. One of the most famous inflammatory mediators is CRP(C-reactive protein) which has been widely used as an inflammatory biomarker for predicting the occurrence of future cardiovascular events. CRP and SAP (Serum Amyloid P component) are referred as classical short pentraxins and are acute phase proteins produced from the liver in response to inflammatory mediators2-3.

Pentraxin 3 (PTX3), a recently identified member of the pentraxin family, is referred to as a long pentraxin and contains a unique PTX3 domain not found in CRP or SAP. In contrast to CRP, PTX3 is produced from the major cell types involved in atherosclerotic lesions, namely vascular endothelial cells, vascular smooth muscle cells, and macrophages,in response to inflammatory stimuli4-7. Moreover, CRP is produced by the liver and represents a systemic response to inflammation, whereas PTX3 is rapidly produced directly from damaged tissues and directly reflects the inflammatory state of the vasculature. PTX3 levels have been reported to be significantly elevated in acute myocardial infarction8, and accordingly, stain treatment significaly decreases PTX3 levels9. Due to the fact that PTX3 is able to reflect ACS condition better than CRP,it is highly possible that PTX3 is a superior biomarker to predict future cardiovascular events11.

<Amino acid sequence of PYX3 and other Pentraxin family members>

<Pentraxins in humoral innate immunity>

<PTX3 production Cells>

Features

*Wide measuring range

*Excellent stability and accuracy

*High specificity

*High reproducibility

Procedure

References

1. Lusis AJ, et al. Nature. 2000;407:233-41
2. Baumann H, et al. Immunol Today. 1994;15:74-80
3. Steel DM, et al. lmmuol Today. 1994;15:81-88
4. Lee GW, et al. J Immunol. 1994;153:3700-7
5. Bottazzi B, et al. J Biol Chem. 1997;272:32817-23
6. Introna M, et al. Blood. 1996;87:1862-72
7. Basile A, et al. J Biol Chem. 1997;272:8172-8
8. Peri G, et al, Ciculation. 2000;102:636-41
9. Morikawa S, et al J Atheroscler Tromb. 2002;9:178-83
10. Garlanda, et al. Annu. Rev. Immunol. 2005;23:337-66
11. Inoue K, et al. Arterioscler.Thromb. Vasc Biol. 2007;27:161-167
Please refer to the Instruction manual for more reference.

Product List

Product Name Cat# Quantity Price

Pentraxin 3 / TSG-14/PTX3 ELISA System

PPX-PP-PD03-E0 96WELL

¥ 120,000
$ 1600
€ 1200

Anti PTX3

PPX-PP-PPZ1228-00 0.1ML

¥ 50,000
$ 667
€ 500

Anti PTX3

PPX-PP-PPZ1723-00 0.1ML

¥ 50,000
$ 667
€ 500

Anti PTX3

PPX-PP-PPZ1724-00 0.1ML

¥ 50,000
$ 667
€ 500

Anti PTX3

PPX-PP-PPJ0069-00 0.1ML

¥ 50,000
$ 667
€ 500

Anti PTX3

PPX-PP-PPZ1272-00 0.1ML

¥ 50,000
$ 667
€ 500

Anti PTX3

PPX-PP-PPZ17105-00 0.1ML

¥ 50,000
$ 667
€ 500

Anti PTX3

PPX-PP-PPZ17115-00 0.1ML

¥ 50,000
$ 667
€ 500

Anti PTX3

PPX-PP-PPZ1773-00 0.1ML

¥ 50,000
$ 667
€ 500

1. Lusis AJ, et al. Nature. 2000;407:233-41 2. Baumann H, et al. Immunol Today. 1994;15:74-80 3. Steel DM, et al. lmmuol Today. 1994;15:81-88 4. Lee GW, et al. J Immunol. 1994;153:3700-7 5. Bottazzi B, et al. J Biol Chem. 1997;272:32817-23 6. Introna M, e