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Reagents for oxidative stress research

Anti 4-HNE Monoclonal Antibody

   Oxidative stress marker product TOP

Background


4-Hydroxy-2-Nonenal
Immunohistochemcal detection of 4-HNE in colorectal carcinoma cells. Adenocarcinoma (arrows) and non tumorous epithelial cells (star).
(S. Kondo, et al.:Free Radical Biology & Medicine 27, p401-410, 1999)

Source Mouse
Immunogen 4-HNE-modified Keyhole Limpet Hemocyanin
Subclass IgG1(kappa)
Clone HNEJ-2
Form Lyophilized Powder
Specificity This antibody show almost negligible reactivity with proteins that were treated with other aldehydes, such as 2-nonenal, 2-hexenal, 1-hexanal, 4-hydroxy-2-hexenal,formaldehyde, or glutaraldehyde.
Applications Immunohistochemistry and Western blotting.
Storage Less than -20°C for 5 years

Oxidative Stress Markers flyer download [PDF]

Product List

Product Name Cat# Quantity Price

Anti 4-HNE

NNS-MHN-100P-EX 100UG

¥ 89,600
$ 1195
€ 896

Anti 4-HNE

NNS-MHN-020P-EX 20UG

¥ 23,100
$ 308
€ 231

References
  •  Toyokuni S. et al., The monoclonal antibody specific for the 4-hydroxy-2-nonenal histidine adduct. FEBS Lett. 1995 Feb 13;359(2-3):189-91. PMID: 7867796
  •  Tanaka T., et al., Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab Invest. 1997 Aug;77(2):145-55. PMID: 9274857
  •  Hattori Y. et al, 8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol. 1996 Nov;107(5):733-7. PMID: 18776701
  •  S.Toyokuni: Reactive oxygen species-induced molecular damage and its application in pathology. Pathol. Internat. 49, p91-102 (1999)
  •  Kondo S. et al, Persistent oxidative stress in human colorectal carcinoma, but not in adenoma. Free Radic Biol Med. 1999 Aug;27(3-4):401-10. PMID: 10468215
  •  Oberley TD. et al, Localization of hydroxynonenal protein adducts in normal human kidney and selected human kidney cancers. Free Radic Biol Med. 1999 Sep;27(5-6):695-703. PMID: 10490290