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useful to a general oxidative stress marker in the body.

Anti 8-OHdG monoclonal antibody

   Oxidative stress marker product TOP



8-Hydroxy-2'-deoxyguanosine
Epidermis from hairless mouse by chronic UVB irradiation after 4 weeks of treatment stained with N45.1.
(Y.Hattori, et.al.:J.Invest.Dermatol. 107, p733-737, 1997)
Source: Mouse
Antigen: 8-OHdG-conjugated Keyhole Limpet Hemocyanin
Subclass: IgG1(kappa)
Form: Lyophilized Powder
Specificity: 19 analogues of 8-OHdG {guanosine (G), 7-methyl-G, 6-SH-G, 8-bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG, 8-OHdA, guanine (Gua), O6-methyl-Gua, 8-OHGua, uric acid, Urea, creatine, creatinine} demonstrate no cross-reactivity. Only 8-sulfhydryl-G and 8-OHG demonstrate minimal cross-reactivity (less than 1%).
Use: Immunohistochemistry
Storage: Less than -20°C for 5 years
Package: Code: MOG-100P, Anti 8-OHdG monoclobal antibody (100 micro gram / vial )
Code: MOG-020P, Anti -OHdG monoclobal antibody (20 micro gram / vial )

Immunohistochemical Procedure for 8-OHdGPDF

Product List

Product Name Cat# Quantity Price

Anti 8-OHdG

NNS-MOG-020P-EX 20UG

¥ 33,300
$ 444
€ 333

Anti 8-OHdG

NNS-MOG-100P-EX 100UG

¥ 128,000
$ 1707
€ 1280

References
  •  Toyokuni S. et al., Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest. 1997 Mar;76(3):365-74. PMID: 9121119
  •  Hattori Y. et al, 8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol. 1996 Nov;107(5):733-7. PMID: 8875958
  •  Tanaka T. et al, Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab Invest. 1997 Aug;77(2):145-55. PMID: 9274857
  •  Ihara Y. et al, Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. Diabetes. 1999 Apr;48(4):927-32. PMID: 10102716
  •  Ichiseki T. et al, DNA oxidation injury in bone early after steroid administration is involved in the pathogenesis of steroid-induced osteonecrosis. DNA oxidation injury in bone early after steroid administration is involved in the pathogenesis of steroid-induced osteonecrosis. PMID: 15598705
  •  Lee YA. et al, Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence. Biol Pharm Bull. 2008 Jun;31(6):1265-9. PMID: 18520066