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Anti Mouse Usp11 Polyclonal Antibody

Background

Usp11 (ubiquitin specific peptidase 11) is possesses Cys box, His box, Asp and KRF domains, which are highly conserved in many ubiquitin-specific proteases. Usp11 is a ubiquitous protein in various tissues and is primarily localized in the nucleus of non-dividing cells. Usp11 binds specifically to RanBPM which is a RanGTP-binding protein required for correct nucleation of microtubles and inhibits its ubiquitination and degradation. It has been also shown that Usp11 is involved in regulation of the TNFα-induced IKKα → p53 signaling pathway and that Usp11 functions in stabilizing HPV-16E7 by reducing ubiquitination and attenuating E7 degradation.

WB Not tested
IHC 5.0-10 µg/mL
ICC Not tested
ELISA Not tested
FCM Not tested
Neutralization Not tested
IP Not tested

<Immunohistochemistry>

Sample: Mouse kidney
(paraffin section)


Sample:Mouse epididymis
(paraffin section)

Product List

Product Name Cat# Quantity Price

Anti Usp11

KAL-KG403 25UG

¥ 49,000
$ 654
€ 490

Citation

References
  • USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity.
    Lin CH, Chang HS, Yu WC.
    J Biol Chem. 2008 Jun 6;283(23):15681-8. PMID: 18408009
  • The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).
    Yamaguchi T, Kimura J, Miki Y, Yoshida K.
    J Biol Chem. 2007 Nov 23;282(47):33943-8. PMID: 17897950
  • Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM.
    Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, Hagiwara E, Aoki A, Ishigatsubo Y.
    Biochem J. 2002 Oct 1;367(Pt 1):87-95. PMID: 12084015

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.