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Anti Mouse Semaphorin 7A Monoclonal Antibody

Background

Semaphorins are a family of phylogenetically conserved soluble and transmembrane proteins. Semaphorins were originally identified as axon guidance factors during neuronal development. Semaphorins are now known to be widely expressed mediators that play significant roles in immune responses and organ morphogenesis.
 Sema7A (also known as CD108) is a glycosylphosphatidylinositol-anchored semaphorin homologous to AHVsema. Sema7A was originally discovered as the John-Milton-Hagen human blood group antigen. Sema7A specially binds to VESPR/CD232/plexin-C1, which confirm that semaphorin is cellular counterpart of AHVsema. Sema7A transcripts are detectable in the embryonic nervous system and in adult tissues, including the brain, spinal cord, lung, and secondary lymphoid organs. Among lymphocyte populations, Sema7A is expressed mainly in activated T cells.
 Sema7A promotes axon outgrowth through beta-1-integrin receptors and contributes to the formation of the lateral olfactory tract. Sema7A expressed on activated T cells stimulates macrophages to produce proinflammatory cytokines through the alpha-1beta-1 integrin.
Sema7A-deficient mice are defective in T cell-mediated immune responses such as contact hypersensitivity and EAE.

Application

WB Not tested
IHC Not tested
ICC Not tested
ELISA 1.0-10 μg/mL
FCM 50 ng/mL
Neutralization Not tested
IP 5.0 μg/mL

Character

Primary Source -
Type Monoclonal
Immunogen Peptide of mouse Sema7A extracellular domain
Raised in Sema7A deficient mouse
Myeloma P3U1
Clone number SKK-7
Isotype IgG1κ
Source Serum-free medium
Purification notes ProteinG
Cross Reactivity Human
Concentration 0.25 mg/mL
Contents(Volume) 25 μg(100 μL/vial)
Label Unlabeled
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Storage Store below 20°C.Once thawed, store at 4°C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Suzuki K. et al.: Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature 2007 Apr 5;446(7136):680-4. Epub 2007 Mar 21.

Product List

Product Name Cat# Quantity Price

Anti Semaphorin 7A

KAL-KO402 25UG

¥ 55,000
$ 734
€ 550

Anti PEDF

KAL-KM037 50UG

¥ 55,000
$ 734
€ 550

Anti Humanin

KAL-KR050 25UG

¥ 49,000
$ 654
€ 490

Anti Addicsin

KAL-KR057 25UG

¥ 49,000
$ 654
€ 490

Anti S14G-Humanin

KAL-KR061 25UG

¥ 49,000
$ 654
€ 490

Anti Dynein

KAL-KR062 25UG

¥ 49,000
$ 654
€ 490

Anti Tau, phospho Ser416

KAL-KR076 25UG

¥ 49,000
$ 654
€ 490

Anti APH-1a

KAL-KR078 25UG

¥ 49,000
$ 654
€ 490

Anti Dab1

KAL-KR080 25UG

¥ 49,000
$ 654
€ 490

Anti MARCKS

KAL-KT042 50UG

¥ 55,000
$ 734
€ 550

Anti KF-1

KAL-KR096 25UG

¥ 49,000
$ 654
€ 490

Anti Autotaxin / ENPP2

KAL-KM105 25UG

¥ 49,000
$ 654
€ 490

Anti Autotaxin / ENPP2

KAL-KM106 25UG

¥ 49,000
$ 654
€ 490

Anti Ccd1

KAL-KM107 25UG

¥ 49,000
$ 654
€ 490

Anti SulfFP1 / sulf-1

KAL-KM108 50UG

¥ 49,000
$ 654
€ 490

Anti SulfFP2 / sulf-2

KAL-KM109 25UG

¥ 49,000
$ 654
€ 490

Anti SulfFP2 / sulf-2

KAL-KM110 25UG

¥ 49,000
$ 654
€ 490

Anti Calnexin

KAL-KK054 50UG

¥ 55,000
$ 734
€ 550

Anti Semaphorin 3B

KAL-KR100 100UG

¥ 49,000
$ 654
€ 490

Anti Semaphorin 4A

KAL-KO401 25UG

¥ 55,000
$ 734
€ 550

Anti Haao

KAL-KG408 25UG

¥ 49,000
$ 654
€ 490

Anti Semaphorin 4D / CD100

KAL-KO453 25UG

¥ 55,000
$ 734
€ 550

Anti PAG

KAL-KO579 200UL

¥ 55,000
$ 734
€ 550

Anti GRHPR

KAL-KC597 50UG

¥ 55,000
$ 734
€ 550

Anti AKR7A3

KAL-KC598 50UG

¥ 55,000
$ 734
€ 550