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Anti Human Urate Transporter 1 (URAT1)Polyclonal Antibody

Package Size 25μg  (250μL / vial)
Format Rabbit polyclonal antibody 0.1mg/mL
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store below -20°C
Once thawed, store at 4°C.  Repeated freeze-thaw cycles should be avoided.
Purification method This antibody was purified from rabbit serum immunized with partial C-terminal peptide of human URAT1 by peptide affinity chromatography.
Working dilution For Immunohistochemistry ; 1〜5μg/mL
For Western blotting ; 0.1〜0.5μg/mL

HGNC* Name

 

SLC22A12 (solute carrier superfamily 22A12 )
*HGNC:Human Gene Nomenclature Committee

 


Immunohistochemistry Sample: Human proximal tubule
Preparation of antibodies and instruction: Kanai Y, Anzai N
Department of Pharmacology and Toxicology, Kyorin University School of Medicine

<Reference>
1. Anzai N., Miyazaki H., Noshiro R., Khamdang S., Chairoungdua A., Shin HJ., Enomoto A., Sakmoto S., Hirata T., Tomita K., Kanai Y., Endou H. : The Multivalent PDZ Domain-Containing Protein PDZK1 Regulates Transport Activity of Renal Urate-Anion Exchanger URAT1 via Its C-terminal    J Biol Chem.2004 Aug 10 in press

2. Ichida K., Hosoyamada M., Hisatome I., Enomoto A., Hikita M., Endou H., Hosoya T. : Clinical and molecular analysis of patients with renal hypouricemia in Japan-infuence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol.Jan;15(1).164-73, 2004

3. Koepsell H., Endou H. : The SLC22 drug transporter family. Pflugers Arch.Feb;447(5).666-76, 2004. Epub 2003 Jul 19.

4. Anzai N., Miyazaki H., Endou H. : Molecular biology of urate transporter. Seikagaku Feb;76(2).101-10, 2004 Review. Japanese. No abstract available

5. Tanaka M., Itoh K., Matsushita K., Wakita N., Adachi M., Nonoguchi H., Kitamura K., Hosoyamada M., Endou H., Tomita K. : Two male siblings with hereditary renal hypouricemia and exercise-induced ARF. Am J Kidney Dis.Dec;42(6).1287-92, 2003

6. Enomoto A., Niwa T., Kanai Y., Endou H. : Urate transporter and renal hypouricemia. Rinsyo Byori. Sep;51(9).892-7.Japanese, 2003

7. Enomoto A., Kimura H., Chairoungdua A., shigeta Y., Jutabha P., Cha SH., Hosoyamada M., Takeda M., Skine T., Igarashi T., Mtsuo H., Kikuchi Y., oda T., Ichida K., Hosoya T., Shimokata K., Niwa T., Kanai Y., Endou H. : Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature.May 23;417(6887).447-52, 2002. Epub 2002 Apr 14.

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.