To eliminate the drug, xenobiotics, a varirety of endogeneous substances, and their metabolites out of the body, specific membrane proteins named transporters are required. There are two major pathways for the elimination, hepatic one through bile and renal one to urine. The transporter fall into various transport systems by the transportative substrate. In particular, oraganic ion transporter family is comprised of organic anion transport family (OAT), oraganic cation transport family (OCT), OCTN/carnitine transport family, and OAT are multispecific organic anion transpoters, the substrates of which include a lot of both endogeneous and exogeneous anions .
Human Organic anion transporter 1(OAT1) encodes a 563 amino acid residue protein, and which is predicted 12 putative membrane-spanning protein. Human OAT1 was found to be expressed predominantly in the kidney and only weakly in the brain. OAT1 mediates the Na+-independent transport of organic anions, such as PAH (ρ-aminohippurate), cyclic nucleotides, prostanoides, dicaroxylates, and many anion drugs. This antibody has been proved to be useful for immunohistochemistry .
HGNC Name:SLC22A6 (solute carrier superfamily 22A6)
HGNC Name:Human Gene Nomenclature Committee
|Package Size||25μg (250μL / vial)|
|Format||Rabbit polyclonal antibody 0.1 mg/mL|
|Buffer||Block Ace as a stabilizer, containing 0.1%Proclin as bacteriostat|
|Storage||Store below -20°C
Once thawed, store at 4°C. Repeated freeze-thaw cycles should be avoided.
|Purification method||This antibody was purified from rabbit serum immunized with synthesized C-end peptide of human OAT1 by peptide affinity chromatography.|
|Working dilution||for immunohistochemistry 5μg/mL|
Human Kidney (frozen section)
Rat Kidney(frozen section)
1. Hosoyamada M., Sekine T., Kanai Y. and Endou H.:Molecular cloning and functional expression of multispecific organic anion transporter from human kidney. Am.J.Physiol. 276(459):F122-F128,1999
2. Sekine T., Cha S.H., Kanai Y.and Endou H.:Molecular biology of multispecific organic anion transporter family (OAT family). Clin.Exp.Nephlrol.3.237-243, 1999
3. Apiwattanakul N., Sekine T., Chairoungdua A., Kanai Y., Nakajima N., Sophasan S.and Endou H.: Transport properties of nonsteroidal anti-inflammatorydrugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol.Pharmacol.55: 847-854,1999
4. Tsuda M., Sekine T., Takeda M., Kanai Y., Kimura M. and and Endou H.: Transport of ochratoxiin A by renal multispecific organic anion transporter 1.J.Pharmacol. Exp. Ther. 289(3): 1301-1305,1999
5. Sekine T., Cha S.H.and Endou H.:The multispecific organic anion transporter (OAT) family. pflugers Arch-Eur.J.Physiol.440.337-350,2000
6. Endou H.:Molecular mechanisms of drug transport. Folia Pharmacol. Jpn. 116. 114-124, 2000
Anti Organic Anion Transporter1
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.