Mammalian amino acid transport system is consisted of large variety of transporters with the reflection of amino acid molecule variety, and is classfied into various transport systems by the transportative substrate selectivity and the Na+ dependence with the reflection of amino acid molecule variety. Related to b0,+ amino acid transporter (rBAT) is identified amino acid transporter that is associated with the cystinuria-related type II membrane glycoprotein. It induces Na+-independent transport of cystine as well as basic and neutral amino acids with the properties of b0,+ amino acid transporter 1 (BAT1) . rBAT1 was found to be related to the genetic disease cystinuria, in which defects in amino acid reabsorption in the renal proximal tubules lead to urinary loss of cystine and basic amino acids. The BAT1 and rBAT proteins were shown to be colocalized in the apical membrane of the renal proximal tubules where massive cystine transport had been proposed, and BAT1 is associated with rBAT to express its function. This antidody has been proved to be useful for immunohistochemistry and immunoblotting.
1. Chairoungdua A., Segawa H., Kim J.Y., Miyamoto K., Haga H., Fukui Y., Mizoguchi K., Ito H., Takeda E., Endou H.and Kanai Y.: Identification of an Amino Acid Transporter Associated with the Cystinuria -related Type II Membrane Glycoprotein. J.Biol.Chem. 274 (41) 28845-28848,1999
2. Mizoguchi K., Cha S.H., Chairoungdua A., Kim D.K., Shigeta Y., Matsuo H., Fukushima J., Awa Y., Akakura K., Goya T., Ito H., Endou H.,and Kanai Y.:Human cystinuria-related transporter :Localization and functional characterization.Kidney Int.59.1821-1833, 2001
Anti Related To b(0,+)-Type Amino Acid Transporter / rBAT
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.