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Unique, efficient transfection of siRNA, DNA, oligonucleotides, proteins.GenomONE - CF EX Low toxicity with primary cell lines.Protocols for in vivo transfection.

GenomONE™ - Neo EX HVJ Envelope Transfection Kit-Reference

Transfection

Plasmid DNA Transfection ( in vivo / in vitro )
Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells.
Takashina M, Inoue S, Tomihara K, Tomita K, Hattori K, Zhao QL, Suzuki T, Noguchi M, Ohashi W, Hattori Y.
Int J Oncol. 2017 Mar;50(3):787-797. PMID: 28197625
Protein Transfection ( in vitro / in vivo ) / Peptide Transfection ( in vitro )
Directly reprogramming fibroblasts into adipogenic, neurogenic and hepatogenic differentiation lineages by defined factors.
Wu W, Jin YQ, Gao Z.
Exp Ther Med. 2017 Jun;13(6):2685-2690. PMID: 28587331
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity.
Kobayashi Y, Ito K, Kanda A, Tomoda K, Mercado N, Barnes PJ.
Mol Pharmacol. 2017 May;91(5):475-481. PMID: 28283554
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality
Zhang H, Luo J, Alcorn JF, Chen K, Fan S, Pilewski J, Liu A, Chen W, Kolls JK, Wang J.
J Immunol. 2017 Jun 1;198(11):4383-4393. PMID: 28424239
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Human monocytes downregulate innate response receptors following exposure to the microbial metabolite n-butyrate
Lasitschka F, Giese T, Paparella M, Kurzhals SR, Wabnitz G, Jacob K, Gras J, Bode KA, Heninger AK, Sziskzai T, Samstag Y, Leszinski C, Jocher B, Al-Saeedi M, Meuer SC, Schroder-Braunstein J.
Immun Inflamm Dis. 2017 Jul 6. PMID: 28681454
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Inhibition of TrkB limits development of the zebra finch song system.
Beach LQ, Tang YP, Kerver H, Wade J.
Brain Res. 2016 Jul 1;1642:467-477. PMID: 27086969
Plasmid DNA Transfection ( in vivo / in vitro )
High-efficiency generation of induced pluripotent mesenchymal stem cells from human dermal fibroblasts using recombinant proteins
Chen F, Zhang G, Yu L, Feng Y, Li X, Zhang Z, Wang Y, Sun D, Pradhan S.
Stem Cell Res Ther. 2016 Jul 30;7(1):99. PMID: 27473118
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Netrin-1 prevents the development of cardiac hypertrophy and heart failure.
Wang N, Cao Y, Zhu Y.
Mol Med Rep. 2016 Mar;13(3):2175-81. PMID: 26783193
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Cathepsin D: an M?-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy.
Monickaraj F, McGuire PG, Nitta CF, Ghosh K, Das A.
FASEB J. 2016 Apr;30(4):1670-82. PMID: 26718887
Plasmid DNA Transfection ( in vivo / in vitro )
Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats.
Hiramatsu M, Hishikawa T, Tokunaga K, Kidoya H, Nishihiro S, Haruma J, Shimizu T, Takasugi Y, Shinji Y, Sugiu K, Takakura N, Date I.
J Neurosurg. 2016 Dec 23:1-8. PMID: 28009234
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation.
Butler PL, Staruschenko A, Snyder PM.
J Biol Chem. 2015 May 15;290(20):12497-503. PMID: 25787079
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis.
Narumi T, Shishido T, Otaki Y, Kadowaki S, Honda Y, Funayama A, Honda S, Hasegawa H, Kinoshita D, Yokoyama M, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Tanaka A, Woo CH, Abe J, Takeishi Y, Kubota I.
J Mol Cell Cardiol. 2015 May;82:1-12. PMID: 25736854
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Manipulation of cardiac phosphatidylinositol 3-kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates cardiomyocyte death during doxorubicin-induced cardiomyopathy.
Kitamura Y, Koide M, Akakabe Y, Matsuo K, Shimoda Y, Soma Y, Ogata T, Ueyama T, Matoba S, Yamada H, Ikeda K.
J Biol Chem. 2014 Jan 31;289(5):2788-800. PMID: 24338479
Plasmid DNA Transfection ( in vivo / in vitro )
Anti-tumor effects of inactivated Sendai virus particles with an IL-2 gene on angiosarcoma.
Takehara Y, Satoh T, Nishizawa A, Saeki K, Nakamura M, Masuzawa M, Kaneda Y, Katayama I, Yokozeki H.
Clin Immunol. 2013 Oct;149(1):1-10. PMID: 23886549
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Multiple functional involvement of thymosin beta-4 in tooth germ development.
Ookuma YF, Kiyoshima T, Kobayashi I, Nagata K, Wada H, Fujiwara H, Yamaza H, Nonaka K, Sakai H.
Histochem Cell Biol. 2013 Feb;139(2):355-70. PMID: 23052839
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus.
Kosmider B, Messier EM, Janssen WJ, Nahreini P, Wang J, Hartshorn KL, Mason RJ.
Respir Res. 2012 Jun 6;13:43. PMID: 22672594
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation.
Kobayashi Y, Mercado N, Miller-Larsson A, Barnes PJ, Ito K.
Pulm Pharmacol Ther. 2012 Jun;25(3):201-7. PMID: 22401993
Plasmid DNA Transfection ( in vivo / in vitro )
Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement.
Zhao N, Lin J, Kanzaki H, Ni J, Chen Z, Liang W, Liu Y.
Am J Orthod Dentofacial Orthop. 2012 Jan;141(1):30-40. PMID: 22196183
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Gene silencing of MK2 in hard-to-transfect human U937 cells.
Tietz SM, Berghoff M.
J Biomol Tech. 2012 Jul;23(2):47-50. PMID: 22951959
Plasmid DNA Transfection ( in vivo / in vitro )
Serum calcium-decreasing factor, caldecrin, ameliorates muscular dystrophy in dy/dy mice.
Tomomura M, Fujii T, Sakagami H, Tomomura A.
In Vivo. 2011 Mar-Apr;25(2):157-63. PMID: 21471529
Review
Efficient in vivo delivery of plasmids and oligonucleotides using hemagglutinating virus of Japan envelope (HVJ-E) vector in immunological disease models.
Kitani A, Fichtner-Feigl S.
Curr Protoc Immunol. 2010 Nov;Chapter 10:Unit 10.17E.1-9. PMID: 21053301
Review
Use of the hemagglutinating virus of Japan (HVJ) envelope as a versatile delivery system for nucleic acids and proteins to leukocytes in vitro.
Kondo Y, Miyata K, Kato F.
Curr Protoc Immunol. 2010 Apr;Chapter 10:Unit 10.17D.1-9. PMID: 20376840
Plasmid DNA Transfection ( in vivo / in vitro )
Zinc-finger transcriptional factor Sall1 induces angiogenesis by activation of the gene for VEGF-A.
Yamamoto C, Fukuda N, Matsumoto T, Higuchi T, Ueno T, Matsumoto K.
Hypertens Res. 2010 Feb;33(2):143-8. PMID: 19942929
Plasmid DNA Transfection ( in vivo / in vitro )
Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43).
Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, Takeya T, Minamisawa S, Lanier SM, Ishikawa Y.
J Biol Chem. 2009 Nov 6;284(45):31431-40. PMID: 19723622
Bioimaging ( ex vivo / in vivo)
Controlled delivery of basic fibroblast growth factor promotes human cardiosphere-derived cell engraftment to enhance cardiac repair for chronic myocardial infarction.
Takehara N, Tsutsumi Y, Tateishi K, Ogata T, Tanaka H, Ueyama T, Takahashi T, Takamatsu T, Fukushima M, Komeda M, Yamagishi M, Yaku H, Tabata Y, Matsubara H, Oh H.
J Am Coll Cardiol. 2008 Dec 2;52(23):1858-65. PMID: 19038683
Plasmid DNA Transfection ( in vivo / in vitro )
Local osteoprotegerin gene transfer to periodontal tissue inhibits lipopolysaccharide-induced alveolar bone resorption.
Chen R, Kanzaki H, Chiba M, Nishimura M, Kanzaki R, Igarashi K.
J Periodontal Res. 2008 Apr;43(2):237-45. PMID: 18086145
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Involvement of apical P2Y2 receptor-regulated CFTR activity in muscarinic stimulation of Cl(-) reabsorption in rat submandibular gland.
Ishibashi K, Okamura K, Yamazaki J.
Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1729-36. PMID: 18337312
Plasmid DNA Transfection ( in vivo / in vitro )
Efficient delivery of antibody into living cells using a novel HVJ envelope vector system.
Kondo Y, Fushikida K, Fujieda T, Sakai K, Miyata K, Kato F, Kato M.
J Immunol Methods. 2008 Mar 20;332(1-2):10-7. PMID: 18221753
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
FKBP51 expressed by both normal epithelial cells and adenocarcinoma of colon suppresses proliferation of colorectal adenocarcinoma.
Mukaide H, Adachi Y, Taketani S, Iwasaki M, Koike-Kiriyama N, Shigematsu A, Shi M, Yanai S, Yoshioka K, Kamiyama Y, Ikehara S.
Cancer Invest. 2008 May;26(4):385-90. PMID: 18443959
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Treatment with vitamin K2 combined with bisphosphonates synergistically inhibits calcification in cultured smooth muscle cells
Saito E, Wachi H, Sato F, Sugitani H, Seyama Y.
J Atheroscler Thromb. 2007 Dec;14(6):317-24. Epub 2007 Dec 17. PMID: 18174662
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation.
Iguchi H, Urashima Y, Inagaki Y, Ikeda Y, Okamura M, Tanaka T, Uchida A, Yamamoto TT, Kodama T, Sakai J.
J Biol Chem. 2007 Jun 29;282(26):19052-61. PMID: 17412698
Plasmid DNA Transfection ( in vivo / in vitro )
Oncostatin M gene therapy attenuates liver damage induced by dimethylnitrosamine in rats.
Hamada T, Sato A, Hirano T, Yamamoto T, Son G, Onodera M, Torii I, Nishigami T, Tanaka M, Miyajima A, Nishiguchi S, Fujimoto J, Tsujimura T.
Am J Pathol. 2007 Sep;171(3):872-81. PMID: 17640959
Bioimaging ( ex vivo / in vivo)
Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.
Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M, Inubushi T, Tsuchiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I.
FEBS Lett. 2007 Feb 6;581(3):475-8. PMID: 17240371
Plasmid DNA Transfection ( in vivo / in vitro )
Preparation and evaluation of gene-transfected cultured skin as a novel drug delivery system for severely burned skin.
Hada N, Todo H, Komada F, Sugibayashi K.
Pharm Res. 2007 Aug;24(8):1473-9. PMID: 17377741
Plasmid DNA Transfection ( in vivo / in vitro )
Efficient gene expression in megakaryocytic cell line using nucleofection.
Isakari Y, Harada Y, Ishikawa D, Matsumura-Takeda K, Sogo S, Ishida T, Taki T, Kiwada H.
Int J Pharm. 2007 Jun 29;338(1-2):157-64. PMID: 17331684
Plasmid DNA Transfection ( in vivo / in vitro )
Transient local overexpression of human vascular endothelial growth factor (VEGF) in mouse feto-maternal interface during mid-term pregnancy lowers systemic maternal blood pressure.
Koyama S, Kimura T, Ogita K, Nakamura H, Khan MA, Yoshida S, Watanabe M, Shimoya K, Kaneda Y, Murata Y.
Horm Metab Res. 2006 Oct;38(10):619-24. PMID: 17075769
Bioimaging ( ex vivo / in vivo)
Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain.
Song Y, Morikawa S, Morita M, Inubushi T, Takada T, Torii R, Kitamura Y, Taniguchi T, Tooyama I.
Histol Histopathol. 2006 Jul;21(7):705-11. PMID: 16598669
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Enhancement of gene transfer activity mediated by mannosylated dendrimer/alpha-cyclodextrin conjugate (generation 3, G3).
Arima H, Chihara Y, Arizono M, Yamashita S, Wada K, Hirayama F, Uekama K.
J Control Release. 2006 Nov;116(1):64-74. PMID: 17083992
decoy ODN Transfection ( in vitro / in vivo) , antisense ODN Transfection ( in vitro)
Mouse model of human infertility: transient and local inhibition of endometrial STAT-3 activation results in implantation failure.
Nakamura H, Kimura T, Koyama S, Ogita K, Tsutsui T, Shimoya K, Taniguchi T, Koyama M, Kaneda Y, Murata Y.
FEBS Lett. 2006 May 15;580(11):2717-22. PMID: 16647058
Plasmid DNA Transfection ( in vivo / in vitro )
Fundamental study of expression-library immunization against Taenia taeniaeformis in rats.
Okamoto M, Matsumoto K, Shibui A, Shibahara T, Ito A.
Southeast Asian J Trop Med Public Health. 2005;36 Suppl 4:135-8. PMID: 16438198
Plasmid DNA Transfection ( in vivo / in vitro )
Comparison of the vector systems for gene transduction into rat dendritic cells and peritoneal exudate cells.
Satoh E, Hara Y, Fuji N, Li XK, Teramoto K, Arii S, Kimura H.
Transplant Proc. 2005 May;37(4):1953-6. PMID: 15919516
Plasmid DNA Transfection ( in vivo / in vitro )
Improvement of gene delivery mediated by mannosylated dendrimer/alpha-cyclodextrin conjugates.
Wada K, Arima H, Tsutsumi T, Chihara Y, Hattori K, Hirayama F, Uekama K.
J Control Release. 2005 May 18;104(2):397-413. PMID: 15907588
Protein Transfection ( in vitro / in vivo ) / Peptide Transfection ( in vitro )
Direct in vivo protein transduction into a specific restricted brain area in rats.
Owada-Makabe K, Tsubota Y, Yukawa K, Kakimoto N, Liang XM, Ichinose M, Maeda M.
Neurosci Lett. 2005 Apr 11;378(1):18-21. PMID: 15763165
Plasmid DNA Transfection ( in vivo / in vitro )
Studies on the most efficient vector systems for gene transduction into dendritic cells.
Satoh E, Yan H, Miyagi T, Li XK, Sugiura W, Yamamoto N, Teramoto K, Arii S, Kimura H.
Transplant Proc. 2005 Jan-Feb;37(1):12-4. PMID: 15808530
Plasmid DNA Transfection ( in vivo / in vitro )
In vivo gene transfer into the mouse uterus: a powerful tool for investigating implantation physiology.
Kimura T, Nakamura H, Koyama S, Ogita K, Tabata C, Tsutsui T, Shimoya K, Koyama M, Kaneda Y, Murata Y.
J Reprod Immunol. 2005 Oct;67(1-2):13-20. PMID: 16111768
siRNA Transfection ( in vitro / in vivo) / miRNA Transfection ( in vitro )
Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation.
Asada M, Ohmi K, Delia D, Enosawa S, Suzuki S, You A, Suzuki H, Mizutani S.
Mol Cell Biol. 2004 Sep;24(18):8236-43. PMID: 15340083
Protein Transfection ( in vitro / in vivo ) / Peptide Transfection ( in vitro )
Noncytotoxic ribonuclease, RNase T1, induces tumor cell death via hemagglutinating virus of Japan envelope vector.
Yuki S, Kondo Y, Kato F, Kato M, Matsuo N.
Eur J Biochem. 2004 Sep;271(17):3567-72. PMID: 15317592
Review
New vector innovation for drug delivery: development of fusigenic non-viral particles.
Kaneda Y.
Curr Drug Targets. 2003 Nov;4(8):599-602. PMID: 14577648
Review
Hemagglutinating virus of Japan (HVJ) envelope vector as a versatile gene delivery system.
Kaneda Y, Nakajima T, Nishikawa T, Yamamoto S, Ikegami H, Suzuki N, Nakamura H, Morishita R, Kotani H.
Mol Ther. 2002 Aug;6(2):219-26. PMID: 12161188

Product List

Product Name Cat# Quantity Price

GenomONE-Neo EX HVJ-E 1 vial Transfection Reagents

ISK-GN-001-EX 1SET

¥ 25,000
$ 334
€ 250

GenomONE-Neo EX HVJ-E 4 vials Transfection Reagents

ISK-GN-004-EX 1SET

¥ 77,000
$ 1027
€ 770

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.