PRODUCT CATEGORY

PRODUCT SEARCH

NEWSLETTER

Register now!Newsletter subscription

  • CATALOG PDF Download
  • BROCHURES PDF Download

LINEAR NF-κB Decoy Oligonucleotides Kits and RIBBON NF-κB Decoy Oligonucleotides Kits

Background

Painful inflammatory diseases such as rheumatoid arthritis and atopic dermatitis are currently treated primarily symptomatically, through the use of analgesics. Thus, there is a great need for novel therapeutics targeting the underlying inflammatory mechanisms. NF-κB is an intensively studied transcription factor well known for its role in stimulating the production of inflammatory cytokines. Recently, NF-κB decoy nucleic acids have gained considerable attention as potential therapeutics for inflammatory disease due to their ability to inhibit NFκB-mediated production of inflammatory cytokines, by preventing NF-κB from binding to its native DNA binding sites. Preliminary studies with NF-κB decoys indicate efficacy in reducing both pain and itch.

First generation NF-κB decoy nucleic acid drugs were linear DNA duplexes. Such drugs suffered not only from poor cellular uptake, but also from serum half-life due to poor resistance to nucleases. Subsequently, a circular (ribbon) form of NF-κB decoy was developed with improved nuclease resistance and significantly longer half-life.

Kit component

Offered here are NF-κB decoy oligodeoxynucleotides kits for our own research. Each kit contains the specified oligo and a control oligo with an identical base composition but different sequence that does not bind NF-κB. Phosphorotioate-modified kits are also offered. Please see the individual product datasheets for exact specifications. All oligos are purified by HPLC

 

Product List

Product Name Cat# Quantity Price

RIBBON NF(KAPPA)B Decoy Oligonucleotides Kit

GDS-DN-25101 2*0.5MG

¥ 65,000
$ 867
€ 650

RIBBON NF(KAPPA)B Decoy Oligonucleotides Kit

GDS-DN-25102 2*0.5MG

¥ 75,000
$ 1000
€ 750

NF(KAPPA)B decoy Oligonucleotides Kit

GDS-DN-15101 2*1MG

¥ 45,000
$ 600
€ 450

NF(KAPPA)B decoy Oligonucleotides Kit

GDS-DN-15102 2*1MG

¥ 55,000
$ 734
€ 550

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.