PRODUCT CATEGORY

PRODUCT SEARCH

NEWSLETTER

Register now!Newsletter subscription

  • CATALOG PDF Download
  • BROCHURES PDF Download

useful for evaluation of cellular or animal models of TDP-43 proteinopathy.

Anti Phosphorylated TDP-43 Antibodies

Go to Antibodies for Neurodegenerative Disease Research page

Background

TDP-43, a heterogeneous nuclear RNA binding protein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases. These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy.

Anti phospho TDP-43 Mouse Monoclonal Antibody (pS409/410)

Antigen : CMDSKS(p)S(p)GWGM, S(p):phosphoserine 409/410

NCIs in dentate gyrus of FTLD-U
MAb pS409/410 stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining. This does not stain ghost tangles and granulovacuolar degeneration in AD or other related diseases by immunohistochemistry.

Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS409/410-1)

Antigen : CMDSKS(p)S(p)GWGM, S(p):phosphoserine 409/410

NCIs in dentate gyrus of FTLD-U
pS409/410-1 sometimes stained ghost tangles and dot-like structures (granulovacuolar degeneration) in the hippocampal and other regions of brains with AD or other related diseases. For this reason, we recommend pS409/410-2 or mAb pS409/410-1 for immunohisochemistry of human tissues.

Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS409/410-2)

Antigen : CMDSKS(p)S(p)GWGM, S(p):phosphoserine 409/410

NCIs in dentate gyrus of FTLD-U
pS409/410-2 stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining. This does not stain ghost tangles and granulovacuolar degeneration in AD or other related diseases.

Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS409)

Antigen : CMDSKS(p)SGWGM, S(p):phosphoserine 409

NCIs and DNs in dentate gyrus of FTLD-U

Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS410)

Antigen : CMDSKSS(p)GWGM, S(p):phosphoserine 410

NCIs and DNs in dentate gyrus of FTLD-U

Anti phospho TDP-43 Rabbit Polyclonal Antibody (pS403/404)

Antigen : NGGFGS(p)S(p)MDSKC, S(p):phosphoserine 403/404

NCIs in dentate gyrus of FTLD-U
pS403/404 stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining. This stains granulovacuolar degeneration in some cases of AD or other related diseases only very weakly.
Go to Antibodies for Neurodegenerative Disease Research page

Product List

Product Name Cat# Quantity Price

Anti TDP-43, phospho Ser409/410

CAC-TIP-PTD-M01 50UL

¥ 50,000
$ 667
€ 500

Anti TDP-43, phospho Ser409/410-2

CAC-TIP-PTD-P02 100UL

¥ 50,000
$ 667
€ 500

Anti TDP-43, phospho Ser409

CAC-TIP-PTD-P03 100UL

¥ 50,000
$ 667
€ 500

Anti TDP-43, phospho Ser410

CAC-TIP-PTD-P04 100UL

¥ 50,000
$ 667
€ 500

Anti TDP-43, phospho Ser403/404

CAC-TIP-PTD-P05 100UL

¥ 50,000
$ 667
€ 500

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.