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marker of cancer stem cells in neurogenic tumors

Anti Nestin Monoclonal antibody

Background

Nestin is an intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian central nervous system (CNS) during development. Nestin is replaced in the adult organism by other intermediate filament proteins, however, it may be re-expressed under certain pathological conditions such as ischemia, inflammation, brain injury, and neoplastic transformation. Nestin has been detected in many kinds of tumors, especially in tumors derived from the CNS, therefore it is considered to be a marker for cancer stem cells in neurogenic tumors.
The antibody was produced from the hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.

Application

1) Immunocytochemistry
2) IImmunohistochemistry


Primary culture of neural progenitor cells from mouse fetal brain stained with 7A3 (Left), stained with Hoechst (Center), and without staing (Right).

<Reference>
1. Hockfield, S., McKay, R.D. (1985) "Identification of major cell classes in the developing mammalian nervous system". J Neurosci. 5: 3310-3328.
2. Gilyarov, A.V. (2008) “Nestin in central nervous system cells” Neuroscience and Behavioral Physiology 38:165-169. 

Product List

Product Name Cat# Quantity Price

Anti Nestin

BAM-73-105-EX 100UL

¥ 34,500
$ 460
€ 345

Anti MiTF

BAM-73-107-EX 100UL

¥ 34,500
$ 460
€ 345

Anti Nucleobindin 2/ NEFA / Nesfatin precursor

BAM-73-109-EX 100UL

¥ 34,500
$ 460
€ 345

Anti PDX1

KAL-KR059 25UG

¥ 49,000
$ 654
€ 490

Anti Initiate Factor 3 / IF3

KAL-KR070 25UG

¥ 49,000
$ 654
€ 490

Anti Keratin 12

KAL-KR074 25UG

¥ 49,000
$ 654
€ 490

Anti Hlxb9

KAL-KR077 25UG

¥ 49,000
$ 654
€ 490

Anti Calpain 6

KAL-KR084 50UG

¥ 49,000
$ 654
€ 490

Anti MFH

KAL-KJ091 50UG

¥ 55,000
$ 734
€ 550