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Anti Rpn7 (S.cerevisiae) polyclonal antibody

Background

The 26 S proteasome is a protein complex with a molecular mass of -2000 kDa and is highly conserved among eukaryotic organisms. It is essential not only for eliminating damaged or misfolded proteins but also for degrading short lived regulatory proteins involved in cell cycle regulation, DNA repair, signal transduction, apoptosis, and metabolic regulation (1). Rpn7 is one of the lid subunits of the 26 S proteasome regulatory particle (1, 2). The RPN7 gene is known to be essential and required for the integrity of the 26 S complex by establishing a correct lid structure (3, 4).

Application

1) Western blotting (-1000 fold dilution)
2) Immunoprecipitation
Not tested for other applications

Anti Rpn7
Detection of Rpn7 (49 kDa) in the crude extract of S. cerevisiae by Western blotting using this antibody.

Product List

Product Name Cat# Quantity Price

Anti Rpn7

BAM-62-205-EX 100UL

¥ 40,000
$ 534
€ 400

References
This product was used in ref.3 and 4.
  • 1. The ubiquitin system. Hershko, A., and Ciechanover, A. THE UBIQUITIN SYSTEM Annu. Rev. Biochem. 67, 425-479 (1998) PMID: 9759494
  • 2. Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Finley D, et al. Trends Biochem Sci 23:244 (1998) PMID: 9697412
  • 3. Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. Isono E, et al. J Biol Chem. 279:27168-76 (2004) PMID: 15102831
  • 4. The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome. Isono E, et al. Mol Biol Cell 18:569-76 (2007) PMID: 17135287

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.