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The Rheumera ELISAsystem allows the measurement of anti-type II collagen antibodies in serum from human.

ELISA Assay Kit to measure human antibodies to type II collagen-Reference


R. B. Clague, K. Morgan, T. I. Reynolds, H. J. Williams. The prevalence of serum IgG antibodies to Type II Collagen in American patients with rheumatoid arthritis. British Journal of Rheumatology, 1994;33:336-338


MJ Rowley, B Tait, T Doran, P Emery and IR Mackay. Associations between HLA and antibodies to collagen in rheumatoid arthritis. Annals of the Rheumatic Diseases, 1990, Vol 49, 578-581.


Kim W.-U., Yoo W.-H., Won Park, Kang Y.-M., Kim S.-I., Park J.-H., Lee S.-S., Joo Y.-S, Min J.-K., Hong Y.- S., Lee S.-H., Park S.-H., ChoC.-S., Kim H.-Y. IgG antibodies to type II collagen reflect inflammatory activity in patients with rheumatoid arthritis. Journal of Rheumatology, 2000; 27(3):575-581.


Rowley MJ, Williamson DJ, Mackay IR Evidence for local synthesis of antibodies to denatured collagen in the synovium in rheumatoid arthritis. Arthritis Rheum. 1987; 30(12):1420-5


Terato K., DeArmey D.A., Ye X.J., Griffiths M.M., Cremer M.A. The Mechanism of Autoantibody Formation to Cartilage in Rheumatoid Arthritis: Possible Cross-Reaction of Antibodies to Dietary Collagens with Autologous Type II Collagen. Clin Imm Immunopath, 1996; 79(2):142-154(13)

Terato K, Shimozuru Y, Katayama K, et al. Specificity of antibodies to type II collagen in rheumatoid arthritis. Arthritis Rheum 1990;33:1493-500.


Andriopoulos NA, Mestecky J, Miller EJ, Bennett JC. Antibodies to human native denatured collagen in synovial fluid of patients with rheumatoid arthritis. Clin Immunol Immunopathol 1976;6:209-12.


Clague RB, Moore LJ. IgG and IgM antibody to native type II collagen in rheumatoid serum and synovial fluid: evidence for the presence of collagen-anticollagen immune complexes in synovial fluid. Arthritis Rheum 1984;27:1370-7.


Fujii K, Tsuji M, Kitamura A, Murota K. The diagnostic significance of anti-type II collagen antibody assay in rheumatoid arthritis. Int Orthop 1992;16:272-6.


Cook AD, Rowley MJ, Stockman A, Muirden KD, Mackay IR. Specificity of antibodies to type II collagen in early rheumatoid arthritis. J Rheumatol 1994;21:1186-91.


Mullazehi M; Mathsson L; Lampa J; Ronnelid J: Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor alpha, interleukin-1beta, and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA: a potential pathophysiologic mechanism for humoral anti-type II collagen immunity in arthritis. Arthritis Rheum. 2006 Jun;54(6):1759-71


Mullazehi M, Mathsson L, Lampa J, Ronnelid J: Anti-collagen type-II antibody levels and induction of proinflammatory cytokines by anti-collagen antibody-containing immune complexes in vitro characterise a distinct rheumatoid arthritis phenotype associated with acute inflammation at the time of disease onset. Ann Rheum Dis. 2007 Apr;66(4):537-41