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Antibodies for Neurodegenerative Disease Research

In rapid aging of society, neurodegenerative diseases such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease are widely-recognized as serious problems that need to be addressed. These unique antibodies offered exclusively by Cosmo Bio are powerful tools in advancing our understanding of neurodegenerative pathologies and mechanisms.

Anti GM3 (NeuAc) Monoclonanl Ganglioside Antibody Clone: M2590

Anti 4R-tau Antibody

Anti C9orf72 Antibodies

Anti phosphorylated TDP-43 Antibodies

Anti α--Synuclein Antibodies

Proteoglycan Antibodies

Anti PON1

1-Oleoyl-Palmitoyl Phosphatidylcholine

 

Anti GM3 (NeuAc) Monoclonanl Ganglioside Antibody Clone: M2590

Ganglioside GM3 is a major glycosphingolipid in the plasma membrane and is widely distributed in all types of animal cells. GM3 has been shown to participate in the pathological conditions of Insulin resistance, and to inhibit VEGF/VEGFR-2-mediated angiogenesis through direct interaction between GM3 and VEGFR-2.
Moreover, GM3 serves as a common precursor for all other ganglioside series gangliosides and hematosides, so this antibody will be extremely useful for the analysis of the biological functions of acidic glycosphingolipids.

  Go to Anti GM3 Page! 

Anti 4R-tau Antibody

This anti-4R antibody recognizes 4-repeat tau (4R-tau) isoforms regardless of the deamidation at Asn279 and strongly stains 4R-tau isoforms in AD brain.

A: Immuno blot analysis of 6 human tau isoforms (3-repeat and 4-repeat) with anti-tau (T46) and anti-4R (CAC-TIP-4RT-P01).

B: Immuno staining of paraffin embedded section of cerebral cortex prepared from AD brain (pretreated with proteinase K and formic acid)

  Go to Anti 4R-tau Page! 

Anti C9orf72 Antibodies

Antibodies raised against dipeptide repeat sequences encoded by C9ORF72 expansions stain the p62-psositive inclusions in FTLD and motor neuron disease.

  Immunostaining of the cerebellum of C9orf72 case for poly-GA protein with anti-GA antibody (CAC-TIP-C9-P01) (By the courtesy of Drs Tada and Takahashi in Niigata Univ). 

  Go to Anti C9orf72 Antibodies Page!

Anti phosphorylated TDP-43 Antibodies

Phosphorylated TDP-43 accumulates in pathological inclusions in brains with FTLD-TDP, ALS, AD, DLB and other neurodegenerative diseases.

NCIs in dentate gyrus of FTLD-TDP MAb pS409/410 stains ubiquitin-positive inclusions in FTLD-TDP and ALS without nuclear staining. This does not stain ghost tangles and granulovacuolar degeneration in AD and other related diseases.
Immunoblot analysis of Sarkosyl-insoluble fractions from control, FTLD-TDP and ALS brains with or without protein phosphatase (PPase) treatment.

  Go to Anti phosphorylated TDP-43 Antibodies Page!

Anti α-Synuclein Antibodies

  Fine tune your α-synuclein research with these antibodies raised against linear epitopes scanning the human α-synuclein sequence.

  Go to Anti α-synuclein Antibodies Page!

α-Synuclein Aggregation Assay Kit

  α-Synuclein Aggregation Assay Kit mimics intracellular aggregation of “α-Synuclein“ seen in Lewy Body Dementia / Parkinson Disease / Multiple system atrophy.
Cell aggregation inhibition and/or preventive effects of your cell culture assay can be tested with this kit.

  Go to α-synuclein Aggregation Assay Kit Page!

Proteoglycan Antibodies

  Proteoglycan are the core structure proteins of the central nervous system (CNS). Antibodies are available for the following proteins: Chondroitin Sulfate A, Neurocans and its peptides, Neuroglycan C, and N-syndecans. Chondroitin sulfate polysaccharides are involved in various cellular events in the formation, regeneration, and maintenance of the neural network. Neurocan are implicated in the neural network formation, and is a susceptibility factor for schizophrenia. N-syndecan plays a pivotal role in formation of the neural network through these molecular interactions.

  Go to Proteoglycan Antibodies Page!

Other Anitbodies

Cosmo also offers antibodies for PON1 and 1-Oleoyl-Palmitoyl-Phosphatidylcholine (OPPC). PON1 polymorphism may be responsible for neuronal protrusions.

  Go to Anti human PON1 Page!

  Go to 1-Oleoyl-Palmitoyl-Phosphatidylcholine (OPPC) Page!

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.