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Anti Multiubiquitin Chain Monoclonal Antibodies

Background

The multiubiquitin chains attached to the protein act as a signal of protein degradation via ubiquitin-proteasomal protein degradation system. Anti multiubiquitin chain monoclonal antibodies detect polyubiquitinated proteins.


Ubiquitin, SUMO & Proteasome Antibodies flyer download [PDF]

Application

Clone FK1 (IgM): WB
This clone does not show any cross reactivities to free ubiquitins or methylubiquitinated proteins that can not form polyubiquitinated protein in Western Blotting.

Clone FK2 (IgG1): WB, ELISA (sandwich method)
This clone shows cross reactivities to methylubiquitinated proteins though this clone does not show any cross reactivities to free ubiquitins1. FK2 is suitable for measurement of polyubiquitinated protein by ELISA (sandwich method)2

Product List

Product Name Cat# Quantity Price

Anti Multiubiquitin, Chain

NBT-MFK-003 0.5MG

¥ 90,000
$ 1200
€ 900

Anti Multiubiquitin, Chain

NBT-MFK-004 1MG

¥ 140,000
$ 1867
€ 1400

References

1. M.Fujimoto, H.Sawada, and H. Yokosawa, FEBS Lett.349,173-180 (1994)
2. K. Takada, H.Nasu, H,Hibi, Y. Tsukada, K. Ohkawa, M.Fujimuro, H. Sawada, and H. Yokosawa, Eur. J. Biochem. 223, 42-47(1995)

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.