The neurotransmitter/hormone adrenaline (epinephrine, adrenalin) play a central role in the mammalian stress response, increasing heart rate, raising blood pressure, and increasing blood glucose levels upon entering the blood stream.
Adrenaline is secreted primarily by the adrenal medulla. Adrenaline activates both α-adrenergic receptors and β-adrenergic receptors. Three subtypes of beta adrenergic receptors are known, β1, β2, β3, expressed primarily in heart, respiratory tissue, and adipose tissue, respectively.
β3-receptors are particularly abundant in brown adipocytes and play an important role in lipolysis and theremoregulation. (Ref.1, Ref.2) Recently this receptor has received attention from researchers interested in type 2 diabetes mellitus and obesity. It is also being considered as a therapeutic target for heart failure (Ref.3).
1 Skeberdis VA.: Structure and function of beta3-adrenergic receptors. Medicina (Kaunas). 2004;40(5):407-13.
2 Walston J. et al. : Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med. 1995 Aug 10;333(6):382-3.
3 Pott C. et al. : Beta3-adrenergic stimulation in the human heart: signal transduction, functional implications and therapeutic perspectives. Pharmazie. 2006 Apr;61(4):255-60.
Sample: Extracted protein from mouse adipose tissue
Anti BETA3 AR
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.