|15-20||Not Tested||100-150||Not Tested|
The data is provided from Division of Gene Regulation Institute for Advanced Medical Research School of Medicine, Keio Univ., Japan
# Function Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
# Subcellular location Membrane ; Single-pass type I membrane protein.
# Tissue specificity Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
# /Sequence similarities Contains 1 Link domain.
|Immunogen||Partial peptide of Human CD44 (DQFMTADETRNLQNVDMKIGV)|
|Purification||Protein G purified|
|Contents (Volume)||200µg (800µL/vial)|
|Buffer||PBS [containing2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]|
|Storage||Store below 20°C. Once thawed, store at 4°C. Repeated freeze-thaw cycles should be avoided.|
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.