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Anti Human AKR7A3 Monoclonal Antibody (Clone No. 2B8)

Application

ELISA WB IHC ICC
1-10 10-20 5.0-10 Not tested
IP FCM IF Neutralization
Not tested Not tested Not tested Not tested

(μg/ml)

 

[IHC] Rat kidney tissue
[IHC] Rat kidney tissue

<Summary>
#  Function // Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
#  Subunit structure// Homodimer.
#  Subcellular location// Cytoplasm.
#  Tissue specificity// Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.
#  Sequence similarities// Belongs to the aldo/keto reductase 2 family.

Character

Type Monoclonal Antibody
Immunogen Partial peptide of Human AKR7A3 (Central region, 173-185aa)
Raised in GANP mouse
Source Serum-free medium
Purification ProteinG
Cross Reactivity Human, Rat
Concentration 0.25 mg/mL
Contents(Volume) 50 μg(200 μL/vial)
Label Unlabeled
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store at - 20℃ long term, store at 4℃ short term. Avoid repeated freeze-thaw cycles.

<Reference>
1. "cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3." Knight L.P.et al. Carcinogenesis 20:1215-1223(1999) [PubMed: 10383892] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANTS MET-138; ASP-215 AND ALA-323. Tissue: Liver.
2. "Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells." Praml C.et al. Oncogene 22:4765-4773(2003) [PubMed: 12879023] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY,VARIANTS ASP-215 AND ALA-323.
3. "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G. et al. Nature 441:315-321(2006) [PubMed : 16710414] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

 

This product is generated from GANP mice

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