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Anti Human GRHPR Monoclonal Antibody


1.0 10-20 Not tested Not tested
IP FCM IF Neutralization
Not tested Not tested Not tested Not tested


<Western blotting>
Sample : lysate from human cancer cell line
1, 2: normal hepatic tissue derived from patient with colon cancer
3, 4: non-tumor tissue drived from patient with hepaticellular cancer
5, 6: hepatic cells derived from patient without recurrent hepaticellular cancer
7, 8: hepatic cells derived from patient with recurrent hepaticellular cancer


# Function: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
# Catalytic activity Glycolate + NADP+ = glyoxylate + NADPH. D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.
# Subunit structure Homodimer. Ref.1 Ref.7
# Tissue specificity Ubiquitous. Most abundantly expressed in the liver. Ref.5
# Involvement in disease Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate. Ref.2
# Sequence similarities Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


Type Monoclonal Antibody
Immunogen Partial peptide of Human GRHPR (C-terminal region)
Raised in GANP mouse
Clone number 7G1
Source Serum-free medium
Purification ProteinG
Cross Reactivity  
Concentration 0.25 mg/mL
Contents(Volume) 50 μg(200 μL/vial)
Label Unlabeled
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store at -20℃ long term, store at 4℃ short term. Avoid repeated freeze-thaw cycles.

1. "Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase." Rumsby G. et al. Biochim. Biophys. Acta 1446:383-388(1999) [PubMed: 10524214] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT. Tissue: Liver.
2. "The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II." Cramer S.D. et al. Hum. Mol. Genet. 8:2063-2069(1999) [PubMed: 10484776] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], INVOLVEMENT IN HP2. Tissue: Liver.
3. Liu B. et al. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Aorta.

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