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Obesity and Metabolic Syndrome Related Antibody

Anti Human PPARγ Polyclonal Antibody

Background

PPARs (peroxisome proliferator-activated receptors) are a family of transcription factors belonging to the nuclear hormone receptor superfamily. Widely expressed in vertebrates, PPARs play critical roles in metabolism and differentiation of a number of cell types. The PPARγ subtype was originally identified as a factor binding to a fatty acid specific enhancer of the aP2 gene. PPAR-γ actions are mediated by three isoforms resulting from alternative promoter selection and alternative splicing. PPAR-γ1 is widely expressed while PPAR-γ2 expression is restricted to adipose tissue and PPAR-γ3 expression is restricted to adipose tissue, macrophage, and colon. PPARγ participates in adipose cell differentiation and energy storage (Ref.1). Recently, these roles of PPARγ have focused attention on PPARγ as a target of the anti-diabetic thiazolidinedione class of drugs (Ref.2).

Application

Western blotting: 1.0g/ml

Package Size: 100g (400L/vial)
Format: Rabbit polyclonal antibody 0.25mg/mL
Buffer: PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage: Store below -20°C. 
Once thawed, store at 4C. Repeated freeze-thaw cycles should be avoided.
Purification method: This antibody was prepared from the serum of a rabbit immunized with a partial peptide representing the C-terminal domain of Human PPARγ and purified by peptide affinity chromatography

Product List

Product Name Cat# Quantity Price

Anti PPAR GAMMA

KAL-KG113 100UG

¥ 39,000
$ 520
€ 390

References
  •  Auwerx J. et al., PAR-gamma: a thrifty transcription factor. Nucl Recept Signal. 2003;1:e006. Epub 2003 Jun 27. PMID: 16604178
  •  Kubota N. et al, PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell. 1999 Oct;4(4):597-609. PMID: 10549291

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.

Latest tool to obesity research

 

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