PPARs (peroxisome proliferator-activated receptors) are a family of transcription factors belonging to the nuclear hormone receptor superfamily. Widely expressed in vertebrates, PPARs play critical roles in metabolism and differentiation of a number of cell types. The PPARγ subtype was originally identified as a factor binding to a fatty acid specific enhancer of the aP2 gene. PPAR-γ actions are mediated by three isoforms resulting from alternative promoter selection and alternative splicing. PPAR-γ1 is widely expressed while PPAR-γ2 expression is restricted to adipose tissue and PPAR-γ3 expression is restricted to adipose tissue, macrophage, and colon. PPARγ participates in adipose cell differentiation and energy storage (Ref.1). Recently, these roles of PPARγ have focused attention on PPARγ as a target of the anti-diabetic thiazolidinedione class of drugs (Ref.2).
Western blotting: 1.0g/ml
|Package Size:||100g (400L/vial)|
|Format:||Rabbit polyclonal antibody 0.25mg/mL|
|Buffer:||PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]|
|Storage:||Store below -20°C.
Once thawed, store at 4C. Repeated freeze-thaw cycles should be avoided.
|Purification method:||This antibody was prepared from the serum of a rabbit immunized with a partial peptide representing the C-terminal domain of Human PPARγ and purified by peptide affinity chromatography|
Anti PPAR GAMMA
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.