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useful for the research of various activities which high molecular hyaluronic acid does not have

Hyaluronic Acid Oligosaccharides (explanation on HA Products)

Background

Hyaluronic acid is one of glycosaminoglycan, which does not include sulfate ester function, and it is isolated from the vitreous body of cow’s eye by Dr. Karl Meyer and his assistant Dr. John Palmer in 1934. Hyaluronic acid is constructed from disaccharide repeating units each consisting of a D-glucronic acid and N-acetyl-D-glucosamine, and it is said that the disaccharide repeating units are 10,000 or more in hyaluronic acid, which exist in a living body. Hyaluronic acid exist in almost all of vertebrate, and distributed in all parts of body, especially distributed in vitreous body, synovial fluid, skin, egg cell, brain and so on. Biological features of high molecular hyaluronic acid is water-retention, maintenance of cell, differentiation control and so on.
Recently, low molecular hyaluronic acid and hyaluronan oligosaccharide become known to have various activities which high molecular hyaluronic acid does not have. As shown in reference 1, recent many papers show that by changing molecular weight the product exhibits quite opposite activities.
For example, HA6 shows “Induction of NO and MMPs in chondrocytes”. PG Research has isolated and purified these hyaluronic acid oligosaccharides (HA Oligosaccharides) as shown below to have endotoxicin-free Oligosaccharides, and has been presenting them for in vitro use.

<Reference>
1. Stern R, et.al. Eur. J. Cell. Biol.85 (2006) 699-715
2. Tawada A, et.al. Glycobiology, 2002; 12(7),421


Fluoresceinamine Labeled Sodium Hyaluronate flyer download [PDF]

Hyaluronan Oligosaccharide 4mer (HA4)

Hyaluronan Oligosaccharide 4mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)2β1→3GlcNAc

Molecular Weight: 820

Hyaluronan Oligosaccharide 6mer (HA6)

Hyaluronan Oligosaccharide 6mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)2β1→3GlcNAc

Molecular Weight: 1221.29

Hyaluronan Oligosaccharide 8mer (HA8)

Hyaluronan Oligo saccharide 8mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)3β1→3GlcNAc

Molecular Weight: 1607.21

Hyaluronan Oligosaccharide 10mer (HA10)

Hyaluronan Oligo saccharide 10mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)4β1→3GlcNAc

Molecular Weight: 1992.51

Hyaluronan Oligosaccharide 12mer (HA12)

Hyaluronan Oligo saccharide 12mer sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)5β1→3GlcNAc

Molecular Weight: 2393.81

Hyaluronan oligosaccharide assortment(HA4, HA6, HA8, HA10, HA12)

Hyaluronan Oligo saccharide assortment (6-12mer) sodium salt
GlcAβ1→3(GlcNAcβ1→4 GlcA)nβ1→3GlcNAc

Product List

Product Name Cat# Quantity Price

Hyaluronan Oligosaccharide 4mer (HA4)

CSR-11001 3MG

¥ 24,000
$ 320
€ 240

Hyaluronan Oligosaccharide 4mer (HA4), Endotoxin Free

CSR-11006 3MG

¥ 55,000
$ 734
€ 550

Hyaluronan Oligosaccharide 6mer (HA6)

CSR-11002 3MG

¥ 24,000
$ 320
€ 240

Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free

CSR-11007 3MG

¥ 55,000
$ 734
€ 550

Hyaluronan Oligosaccharide 8mer (HA8)

CSR-11003 3MG

¥ 29,000
$ 387
€ 290

Hyaluronan Oligosaccharide 8mer (HA8), Endotoxin Free

CSR-11008 3MG

¥ 70,000
$ 934
€ 700

Hyaluronan Oligosaccharide 10mer (HA10)

CSR-11004 3MG

¥ 37,000
$ 494
€ 370

Hyaluronan Oligosaccharide 10mer (HA10), Endotoxin Free

CSR-11009 3MG

¥ 80,000
$ 1067
€ 800

Hyaluronan Oligosaccharide 12mer (HA12)

CSR-11005 1MG

¥ 42,000
$ 560
€ 420

Hyaluronan Oligosaccharide 12mer (HA12), Endotoxin Free

CSR-11010 1MG

¥ 72,000
$ 960
€ 720

Hyaluronan oligosaccharide assortment (HA4, HA6, HA8, HA10, HA12)

CSR-93001 1SET

¥ 125,000
$ 1667
€ 1250

Hyaluronan oligosaccharide assortment (HA4, HA6, HA8, HA10, HA12), Endotoxin Free

CSR-93002 1SET

¥ 270,000
$ 3600
€ 2700

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.