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Useful for detection of the hyaluronan (HA)

Hyaluronan Binding Protein [rHABP]

Background

Hyaluronan binding protein rHABP is produced by expression induced culturing in the presence of IPTG using E.coli BL21(DE3)RIL transfected with human versican G1-domain expression vector pRK172VG1.  As compared with animal-derived HABP, the high biological safety is confirmed.  rHAB doesn't bind to other Glycosaminoglycan and DNA and specifically detects the hyaluronan (HA).
Biotin is attached to rHAB to make the biotin-HABP.


Fluoresceinamine Labeled Sodium Hyaluronate flyer download [PDF]

Features & Usage

Histochemistry and Cytochemistry.
Detection of membrane-transferred hyaluronan,
ELISA,
hyaluronan purification with affinity column

Application


Sample: Human Skin
rHABP.-biotin (Cat# HKD-BC41) 2 µg / ml

Product List

Product Name Cat# Quantity Price

Hyaluronan Binding Protein [HABP]

HKD-BC40 50UG

¥ 18,000
$ 240
€ 180

Hyaluronan Binding Protein [HABP]

HKD-BC41 50UG

¥ 36,000
$ 480
€ 360

References
  • 1. Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides. Seyfried NT,et al J Biol Chem. 2005 Feb 18;280(7): 5435-48. Epub 2004 Dec 8. PMID: 2583089
  • 2. Multiple domains of the large fibroblast proteoglycan, versican. Zimmermann DR, Ruoslahti E. EMBO J. 1989 Oct;8(10):2975-81 PMID: 2583089
  • 3. A comparative study of the binding of cartilage link protein and the hyaluronate-binding region of the cartilage proteoglycan to hyaluronate-substituted Sepharose gel. Biochem J. 1981 Nov 1;199(2):297-305 PMID: 7340806
  • 4. Quantitative analysis of hyaluronate in nanogram amounts. Biochem J. 1980 Jan 1;185(1):101-5. PMID: 6445729

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.