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useful for the immunological study in HBV and the research of the infection mechanism

Hepatitis B Virus Surface Antigen (HBsAg), L-protein, Recombinant


HBsAg is the surface antigen of Hepatiis B virus (HBV). HBsAg is known to be present in blood if HBV infected patients, and used as a important diagnostic maker of HBV infection. HBsAg forms a small lipid particle(diameter 50 to 60nm)in which many antigen protein are present. Each antigen protein has three domains, called S, Pre-S1 and Pre-S2. L-type antigen contains all the three domains, M-type antigen contains S- and Pre-S2, and S-type antigen consisted of only S-domains. During the process of HBV infection, Pre-S1 domain plays a key role for host (haptic) cell recognition, and Pre-S2 domain is essential for cell penetration. In infected patients, hepatic cells produces a lot of non-infectious S-type HBsAg (HBV mimetics without genome). The detection of serum Pre-S2 and Pre-S1 antigen is, therefore, very important to reveal the mechanism of HBV infection. Beacle has a decade of R&D history on HBsAg and related materials, and developed the production process of various HBsAgs and Bionanocapsule (a kind of form of HBsAg) for DDS purpose. We now supply these HBsAg-related products.

Feature and Advantages

Our HBs antigens are all recombinant antigen produced in yeast or E.coli. Therefore, antigens shows stable quality, and does not cause HBV infections. We also supply HBs-related antibodies, good for western and ELISA.


Pre-S1 activity is more than 1000 units
(Unit are arbitrary scale determined in Beacle using Pre-S1 detecting ELISA system)


Nano size particles having antigen protein floating in lipid bilayer. The mean particle size is 60 to 70nm as determined dynamic light scattering methods (20 nm as determined by electron microscopy)

SDS-PAGE with silver staining

Product List

Product Name Cat# Quantity Price

Hepatitis B Virus Surface Antigen (HBsAg), L-protein


¥ 80,000
$ 1067
€ 800

HBsAg with high antigenic activity (HBsAg-XT)


¥ 80,000
$ 1067
€ 800

Anti HBs Pre-S1


¥ 30,000
$ 400
€ 300

Anti HBs, S-protein


¥ 30,000
$ 400
€ 300

HBsAg, Pre-S1 peptide Thioredoxin-His Tag


¥ 60,000
$ 800
€ 600

HBsAg, Pre-S2 peptide


¥ 80,000
$ 1067
€ 800

HBsAg, Pre-S2 peptide Thioredoxin-His Tag


¥ 60,000
$ 800
€ 600

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.

< Reagent related to infectious disease >

  • HBsAg Subtype EIA [IIM-1A63C]
    This kit is a kit for the HBs (hepatitis B surface) antigen subtype judgment by the monoclonal antibody.
  • HBV Pre-S1 Antigen Quantitative ELISA Kit (High Sensitivity) [BEC-BCL-S1H-01]
    This kit is Pre-S1 antigen detection kit in human serum or plasma.
  • HBV Pre-S2 quantitative ELISA kit (coming soon)
    This kit is Pre-S2 antigen detection kit.
  • HB S-Antigen Quantitative ELISA Kit (high sensitivity) [BEC-BCL-SH-01]
    This kit is HBV S-Antigen detecting ELISA kit
  • IMMUNIS HBV Genotype EIA
    This product is an enzyme immunoassay (EIA) based HBV genotyping kit, designed to determine genotype (A, B, C, or D) by detecting genotype-specific epitopes in PreS2 region .
  • HCV Genotype Primer Kit [IIM-8C01C]
    This kit is a primer kit for RT-PCR that can classify HCV into I(1a), II(1b), III(2a), IV(2b), and the V(3a) type by the difference of gene sequences of the core area.
  • Anti HCV core monoclonal antibodies
  • IgG/IgM anti HEV EIA [IIM-1Z23]
    This kit is a reagent that detects IgG anti HEV antibody or IgM anti HEV antibody respectively.

< Reagent related to HGF(Hepatocellular Growth Factor) >