Immunofluorescence: Mouse Peyer's Patch
FCM: Mouse FACAMR expressing Ba/F3 Cells
FCM: Human FACAMR expressing Ba/F3 Cells
Function: Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed in several tissues including thymus, spleen, liver, kidney, small and large intestine, testis and placenta. Expressed by oligodendrocytes, B cells and macrophages but not granulocytes, T cells or NK cells (at protein level).
Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
1. Shibuya A, et al. "Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes." Nat Immunol. 2000 Nov;1(5):441-6.
2. Cho Y, et al. "Molecular characteristics of IgA and IgM Fc binding to the Fcalpha/muR." Biochem Biophys Res Commun. 2006 Jun
23;345(1):474-8. *Application Reference
3. Honda S, et al. "Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice." Proc Natl
Acad Sci U S A. 2009 Jul 7;106(27):11230-5.
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.