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Useful for clarifying an immunologic mechanism in a Fish and Human Immunology Research

Anti CD8(α) Monoclonal Antibody

Background

T cell coreceptor CD8 exists on mature T cells as homodimers of CD8α polypeptide chains and heterodimers of CD8α- and CD8β- chains. T-cells expressing the CD8 surface antigens cnstitute an important component of the specific effector mechanism in immunosurveillance against virus-infected or transformed cells, and are thus termed cytotoxic T-lymphocytes (CTLs). CD8+ CTL recognize endogenously derived peptides in the context of the MHC class I molecule. This recognition process also involves CD8 which binds to the α3-domain of the MHC class Ia molecule.

Application notes

  • Fluorescence - activated cell sorter: 5 ug/ml (Ref. 1)
  • Immuno-histochemistry: 5 ug/ml (Ref. 2)
  • Optimal dilutions/concentrations should be determined by the end user.

Product List

Product Name Cat# Quantity Price

Anti CD8(ALPHA)

CAC-NIH-NA-02 50UL

¥ 40,000
$ 534
€ 400

References

  • Toda H., et al. Allo-antigen specific killing is mediated by CD8 positive T cells in fish. Dev. Comp. Immunol. (2009) 33 (4), 646-652.
  • Shibasaki Y., et al. Kinetics of lymphocyte subpopulations in allogeneic grafted scales of ginbuna crucian carp. Dev Comp Immunol. (2015) 52(1), 75-80.

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.