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Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen

Stachybotrydial

Stachybotrydial is a tripenylphenol metabolite (molecular mass of 386.5) produced by the fungus Stachybotrys sp.(e.g. S.cylindrospora, S. nephrospora)(1-7).

Stachybotrydial inhibits pancreatic cholesterol esterase at IC50 of 60 μM. When administered to normal rats (100 mg/kg, po), reduced cholesterol absorption by 50-60%. In cholesterol-fed mice, dietary supplementation of stachybotrydial (0.1%) for 14 days resulted in 20% reduction in serum total cholesterol level without causing significant change in the high density lipoprotein cholesterol level (3).

Stachybotrydial inhibits avian myeloblastosis virus protease, myo-inositol monophosphatase, fucosyltransferases and syalyltransferases at IC50 of 7.8 μM, 70 μM, 0.6-10 μg/mL and 11-21 μg/mL, respectively (4-6).
Stachybotrydial has antiviral activity against herpes simplex virus 1 (IC50 = 4.32 μg/mL), antiplasmodial activity (IC50 = 0.85 μg/mL) (7).

Stachybotrydial enhanced fibrin binding andactivation of plasmingen (2- to 4-fold at 60-120 μM) (8).

References

1. Ayer, W. A. and S. Miao (1993). "Secondary metabolites of the aspen fungus Stachybotrys cylindrospora." Can J Chem 71: 487-93.
2. Jarvis, B. B. (2003). "Stachybotrys chartarum: a fungus for our time." Phytochemistry 64: 53-60.
3. Sakai, K., E. Akira, et al. (1995). "Isolation, characterization and biological activities of novel triprenyl phenols as pancreatic cholesterol esterase inhibitors produced by Stachybotrys sp. F-1839" J Antibiot(Tokyo) 48(6): 447-56.
4. Kaneto, R., S. Mizuno, et al. (1994). "Mer-NF5003B, E and F, novel sesquiterpenoids as avian myeloblastosis virus protease inhibitors produced by Stachybotrys sp." J Antibiot(Tokyo) 47(6): 727-30.
5. Stefanelli, S., K. Islam, et al. (1996). "Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors Aand C. Isolation, physico-chemical characterization and biological properties" J Antibiot(Tokyo) 49(7): 611-6
6. Lin, T.-W., Y.-C., Tsai, et al. (2005). "Stachybotrydial, a potent inhibitor of fucosyltransferase asn sialyltransferase" Biochem Biophys Res Commun 331: 953-7.
7. Sawadjoon, S., Y. Thebtaranonth, et al. (2004). "Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora." Planta Med 70 (11): 1085-7.
8. Sasaoka, M., K. Hasumi, et al. (2007). "Stachybotrydial selectively enhances fibrin binding and activation of Glu-plasminogen." J Antibiot(Tokyo) 60(11): 674-81.

1. Ayer, W. A. and S. Miao (1993). "Secondary metabolites of the aspen fungus Stachybotrys cylindrospora." Can J Chem 71: 487-93. 2. Jarvis, B. B. (2003). "Stachybotrys chartarum: a fungus for our time." Phytochemistry 64: 53-60. 3. Sakai, K., E. Akira, e

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.

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