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AteloCell® Characteristics of Atelocollagen

Atelocollagen is a collagen solubilized by protease, but its physical properties are virtually identical to those of natural, unsolubilized collagen. Furthermore, atelocollagen additionally has superior characteristics;

Low antigenicity

Atelocollagen is a highly purified type I collagen of calf dermis with protease treatment. A collagen molecule has an amino acid sequence called a telopeptide at both N and C termini, which confers most of the collagen’s antigenicity. Atelocollagen obtained by protease treatment is low in immunogenicity because it is free from telopeptides.


High purity

Atelocollagen is generally obtainable with a high degree of purity. This feature is due to the protease treatment, which when used to extract atelocollagen breaks down other protein contaminations.

High biocompatibility

Atelocollagen is biodegradable. Therefore, atelocollagen is used in a variety of fields such as medicine, medical devices and cosmetics as a raw material, and research in cell culture.


High placiticity

Atelocollagen can be engineered into many different physical shapes such as films, sponge-like structure, string-like configurations, powders and gels. It is possible to leverage the special properties of atelocollagen to produce the most appropriate configuration for any application. For example, atelocollagen is normally insoluble in water with neutral pH, but this characteristic can be altered to make it soluble. It is also possible to use atelocollagen equally as a coagulant or as an anticoagulant, and it is also possible to control the rate at which it is absorbed by the body.


High safety

KOKEN ensures the safety of materials through the precise management of each and every bovine used as a source of material for atelocollagen production;

  1. The bovine dermis we use comes from Australia which has a national livestock traceability system in place, and we only use calves aged six months or younger.
  2. We do not use animal feed derived from bovine and sheep but only BSE-free, safe feed.
  3. We only use the dermal layer of the skin, which is classified as belonging to the "no detectable infectivity" category (WHO Guidelines on Tissue Infectivity Distribution in Transmissible Spongiform Encephalopathies). We take great care to prevent this layer from coming into contact with hazardous sites including the brain and the spine during collection.
  4. We are able to track bovine used for KOKEN's collagen to their birthplace, and we periodically conduct field research.

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.

< Collagen for Cell Culture : AteloCell >