Atelocollagen is a collagen solubilized by protease, but its physical properties are virtually identical to those of natural, unsolubilized collagen. Furthermore, atelocollagen additionally has superior characteristics;
Atelocollagen is a highly purified type I collagen of calf dermis with protease treatment. A collagen molecule has an amino acid sequence called a telopeptide at both N and C termini, which confers most of the collagen’s antigenicity. Atelocollagen obtained by protease treatment is low in immunogenicity because it is free from telopeptides.
Atelocollagen is generally obtainable with a high degree of purity. This feature is due to the protease treatment, which when used to extract atelocollagen breaks down other protein contaminations.
Atelocollagen is biodegradable. Therefore, atelocollagen is used in a variety of fields such as medicine, medical devices and cosmetics as a raw material, and research in cell culture.
Atelocollagen can be engineered into many different physical shapes such as films, sponge-like structure, string-like configurations, powders and gels. It is possible to leverage the special properties of atelocollagen to produce the most appropriate configuration for any application. For example, atelocollagen is normally insoluble in water with neutral pH, but this characteristic can be altered to make it soluble. It is also possible to use atelocollagen equally as a coagulant or as an anticoagulant, and it is also possible to control the rate at which it is absorbed by the body.
KOKEN ensures the safety of materials through the precise management of each and every bovine used as a source of material for atelocollagen production;
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.