CD71 (also known as TFRC: transferrin receptor) is a widely expressed 180 kDa type II membrane glycoprotein involved in the cellular uptake of iron and in the regulation of cell growth. Iron uptake occurs via the internalization of iron-loaded transferrin mediated by the interaction with the CD71. CD71 expression is increased on rapidly proliferating cells, while expression is decreased or absent on non-dividing cells. Some studies have suggested that biologically aggressive tumors require large amounts of iron for active metabolism and rapid cell growth, and overexpression of CD71 has reported in different types of cancers such as glioma, pancreatic, and colon cancers. In addition, CD71 is required for adult erythropoiesis and involved in T- and B- cell development. CD71 seems to play an important role in T cell activation, and T cells lacking CD71 are completely arrested at a very early stage of maturation. This antibody is specific to human CD71 and will be useful for FCM, immunoprecipitation.
1. Not for diagnostic use. The safety and efficacy of product in diagnostic or other clinical uses has not been established. 2. Harmful by inhalation, in contact with skin and if swallowed. Do not breathe dust. Avoid contact with skin and eyes. 3. If contact with skin and eyes, wash all affected areas with large volume of water. If inhaled remove to fresh air. In severe case obtain medical attention. 4. Wash hand thoroughly after handling the product. 5. Do not use this product if container is broken or some contaminants are detected. 6. When preserving the product, Close the container, ensure it does not fall aside or down. 7. Dispose of the container and expired reagents in accordance with federal, state and local government regulations. 8. Do not use the container and accessories of the product for other purpose.
Anti CD71 / TFRC
Bayer AL.. et al.:Transferrin receptor in T cell activation and transplantation. J Leukoc Biol.
Ned RM. et al.:Transferrin receptor 1 is differentially required in lymphocyte development. Blood. 2003 Nov 15;102(10):3711-8. Epub 2003 Jul 24.
H?gemann-Savellano D. et al.: The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia. 2003 Nov-Dec;5(6):495-506.
Moura IC. et al.: A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients. Blood.
2004 Mar 1;103(5):1838-45. Epub 2003 Oct 30
Kasibhatla S. et al.: A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12095-100. Epub 2005 Aug 15.
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.