CD54 (also known as ICAM-1: intercellular adhesion molecule-1) is a transmembrane glycoprotein of the immunoglobulin superfamily of adhesion molecules. CD54 expression is constitutive on many cell types. CD54 is a inducible ligand for LFA-1 (lymphocyte function associated antigen) and functions cell-to-cell interactions in inflammatory and immune responses. Some studies have showed that the elevated expression of CD54 occurred in a variety of diseases, including autoimmune diseases, endocrine diseases, and some cancers as gastric, pancreatic, breast cancer. Surface expressed CD54 is apparently shed from the cells and then circulates as soluble ICAM-1 (sICAM-1). sICAM-1 can compete with cell surface CD54 to bind LFA-1 on T lymphocytes. Shedding of CD54 by circulating tumor cells may allow their escape from surveillance by cytotoxic T and natural killer cells, and promote metastasis. It has been suggested that sICAM-1 levels were found to be related tumor presence, clinical stages, and grade. This antibody is specific to human CD54 and will be useful for FCM, immunoprecipitation
1. Not for diagnostic use. The safety and efficacy of product in diagnostic or other clinical uses has not been established.
2. Harmful by inhalation, in contact with skin and if swallowed. Do not breathe dust. Avoid contact with skin and eyes.
3. If contact with skin and eyes, wash all affected areas with large volume of water. If inhaled remove to fresh air. In severe case obtain medical attention.
4. Wash hand thoroughly after handling the product.
5. Do not use this product if container is broken or some contaminants are detected.
6. When preserving the product, Close the container, ensure it does not fall aside or down.
7. Dispose of the container and expired reagents in accordance with federal, state and local government regulations.
8. Do not use the container and accessories of the product for other purpose.
Anti CD54 / ICAM-1
Gho YS. et al.:Stimulation of tumor growth by human soluble intercellular adhesion molecule-1 Cancer Res. 2001 May 15;61(10):4253-7
Yu Y. et al.: The significance of serum soluble intercellular adhesion molecule 1 and transforming growth factor alpha in patients with nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Oct;130(10):1205-8
Kang X. et al.:Clinical evaluation of serum concentrations of intercellular adhesion molecule-1 in patients with colorectal cancer World J Gastroenterol. 2005 Jul 21;11(27):4250-3.
Rosette C. et al.: Role of ICAM1 in invasion of human breast cancer cells. Carcinogenesis. 2005 May;26(5):943-50. Epub 2005 Mar 17.
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.