SIRPβ (signal-regulatory protein β) is a transmembrane protein that is expressed in hematopoietic cells. It has been suggested that SIRPβ promotes phagocytosis in macrophages by inducing the tyrosine phosphorylation of DAP12, Syk, and SLP-76 and the subsequent activation of a MEK-MAPK-myosin light chain kinase cascade (ref. 1).
Western Blot: 1/100-1/200.
(Predicted molecular weight: 50-70 kDa)
Optimal dilutions/concentrations should be determined by the end user.
Hiroshi Ikeda, Sei-ichiro Motegi, Naoko Aoki, Shoji Kimura, Masahiko Mizuki and Takashi Matozaki, Positive Regulation of Phagocytosis by SIRPβ and Its Signaling Mechanism in Macrophage, The Journal of Biological Chemistry, Vol.279 No.28, pp29450-29460
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.