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useful for the research of a role in apoptosis, mitochondrial morphology and autophagy

Anti Atg7 (Clone: ATG7-2) Monoclonal antibody

Background

Autophagy is an evolutionaly conserved machinery, in which autophagosome fuses with lysosome and degrades bulk cytoplasmic contents. Autophagy is involved in many physiological processes such as development, infection, cancer, and neurodegenerative diseases. ATG (autopha gy-related) genes were identified by genetic screening in yeast. Atg7 acts as an E1-like enzyme in both Atg12 and Atg8 ubiquitin-like conjugation systems. Atg7 transfers Atg12 to an E2-like enzyme Atg10, and conjugates Atg12 to Atg5. In the other hand, Atg7 transfers Atg8 to another E2-like enzyme Atg3, and conjugates Atg8 to phosphatidylethanolamine. Many of these ATG genes are conserved also in mammals. Atg7 deficient neonates die soon after birth as they cannot endure perineonatal starvation. Conditional deletion of Atg7 in nerves system results in neurodegeneration with ubiquitin containing aggregates.

Application

Anti ATG7 antibody
Sample: Lysate of Hela Cells

Applying Campaign Price (from July 1st - November 30th, 2017)

⇒ Autophagy antibody products 30% discount campaign

Product List

Product Name Cat# Quantity Price

Anti ATG7

CAC-CTB-AT7-M01 50UG

¥ 35,000
$ 667
€ 500

References
  • 1. Klionsky and Emr, Autophagy as a regulated pathway of cellular degradation. 2000, Science, 290, 1717-21 PMID: 11099404
  • 2. Mizushima et al., Autophagy fights disease through cellular self-digestion. 2008, Nature, 451, 1069-75 PMID: 18305538
  • 3. Tsukada and Ohsumi, Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. 1993, FEBS Lett, 333, 169-74 PMID: 8224160
  • 4. Komatsu et al., Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. 2005, J Cell Biol, 169, 425-34 PMID: 15866887
  • 5. Komatsu et al., Loss of autophagy in the central nervous system causes neurodegeneration in mice. 2006, Nature, 441, 880-4 PMID: 16625205

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.