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useful for the research of diabetic, inflammation, atherosclerosis and tumors.

Anti human Adiponectin Monoclonal Antibody

Background

Obesity is a common etiology of diabetes mellitus and other diseases. Certain adipocytokines are considered beneficial due to their ability to enhance insulin sensitivity, while others, considered detrimental, enhance insulin resistance. 
The beneficial adipocytokine adiponectin displays both anti-diabetic and anti-arteriosclerotic effects. Two distinct adiponectin receptors have been identified. Both AdipoR1 and AdipoR2 are seven-pass transmembrane receptors but are structurally, topologically, and functionally distinct from G-protein coupled receptors (GPCR) (Ref.1). AdipoR1 is most abundant in muscle whereas AdipoR2 is most abundant in liver. Both receptors promote fatty acid oxidation and glucose uptake by AMP-activated protein kinase and PPARalpha 
PPAR agonists are reported to increase expression of activated adiponectin. PPARα agonists also increase expression of adiponectin receptors (Ref.2). Such findings have focused attention on the role of AdipoR1 in PPAR agonist development.

 

<References>
1 Yamauchi T. et al.: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003 Jun 12;423(6941):762-9.
2 Tsuchida A. et al. : Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem. 2004 Jul 16;279(29):30817-22.

Application


Lane 1: Denaturing recombinant Adiponectin.
Lane 2: Non-denaturing recombinant Adiponectin.
The protein bands were visualized with ECL detection system

Product List

Product Name Cat# Quantity Price

Anti AdipoR 1

KAL-KG114 100UG

¥ 39,000
$ 520
€ 390

Anti ADIPOR2

CAC-CNP-ADIPOR2-150 100UL

¥ 40,000
$ 534
€ 400

Anti PPAR GAMMA

KAL-KG113 100UG

¥ 39,000
$ 520
€ 390