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Anti Chondromodulin-I Monoclonal Antibody

Chondromodiulin-1(ChM-1) is a 121-amino acid residue glycoprotein (25-kDa), which was initially identified as a cartilage-specific functional matrix component that stimulates the growth and matrix synthesis of primary cultured chondrocytes in vitro. ChM-1, subsquently, was found to inhibit th e proliferation of vascular endothelial cells as well as as tube morphogenesis in vitro.ChM-1 is highly expressed in the avascular zones of cartilage. Recently,
ChM-1 has been reported to be highly expressed in nomal cardiac valves but at markedly reduced levels in valvular heart disease and maintain cardiac valvular functon by preventing angiogenesis in vivo.

References

1) Hiraki Y. et al. Identification of Chondromodulin I as a novel endothelial cell growth inhibitor. J.Biol.Chem. 271, 22657-62 (1996).
2) Hiraki Y. et al. Molecular cloning of human chondromodulin-I , a cartilage derived growth modulating factor, and its expression in Chinese hamster ovary cells. Eur. J.Biochem. 260, 869-78 (1999).
3) Nakamichi Y. et al. Chondromodulin-I is a bone remodeling factor Mol.Cell.Biol. 23, 636-44 (2003).
4) Yoshioka Y. et al. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. Nature Med. 12, 1151-59 (2006).
5) Miura S.et al. Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-1, a cartilage-derived angiogenesis inhibitor. Exp.Cell.Res. 316, 775-788 (2010)

Product List

Product Name Cat# Quantity Price

Anti Chondromodulin-I

CAC-TCS-001 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-002 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-003 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-004 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-005 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-006 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-007 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-008 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-009 100UG

¥ 60,000
$ 800
€ 600

Anti Chondromodulin-I

CAC-TCS-010 100UG

¥ 60,000
$ 800
€ 600

1) Hiraki Y. et al. Identification of Chondromodulin I as a novel endothelial cell growth inhibitor. J.Biol.Chem. 271, 22657-62 (1996). 2) Hiraki Y. et al. Molecular cloning of human chondromodulin-I , a cartilage derived growth modulating factor, and its

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.