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Anti Rpn9 (S.cerevisiae) polyclonal antibody

Background

The 26 S proteasome is a protein complex with a molecular massof 2,000 kDa. It is essential not only for eliminating damaged or misfolded proteins but also for degrading short lived regulatory proteinsinvolved in cell cycle regulation, DNA repair, signal transduction, apoptosis, and metabolic regulation (ref.1). The 26S proteasome is composed of the 20S core particle (CP) and the 19S regulatory particle (RP). The RP is further subdivided into lid and base sub-complexes. Rpn9 is one of the non-ATPase subunits of lid. Rpn9 plays a key role in facilitating the assembly of the 26S proteasome or in stabilizing the structure of the 26S proteasome. Rpn9 null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects.

Data Link SGD RPN9/YDR427W

Application

1) Western blotting (1/1,000 - 1/2,000)
2) Immunoprecipitation

Anti Rpn9
Western blotting.
Detection of Rpn9 (46kD) in the crude extract of S. cerevisiae

Product List

Product Name Cat# Quantity Price

Anti Rpn9

BAM-62-207-EX 100UL

¥ 42,000
$ 560
€ 420

References
  • 1. The ubiquitin system. Hershko, A., and Ciechanover, A. THE UBIQUITIN SYSTEM Annu. Rev. Biochem. 67, 425-479 (1998) PMID: 9759494
  • 2. Rpn9 is required for efficient assembly of the yeast 26S proteasome. Takeuchi J et al. Mol Cell Biol 19:6575-6584 (1999) PMID: 10490597

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.