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useful for research on analgesia, water diuresis, dysphoria, antipruritic effects, and attenuation of cocaine craving in addicts.

Anti Human KOR Monoclonal Antibody (Clone No. 5E3)

Background

OPRK1 (opioid receptor, kappa 1), also known as KOR, belongs to the rhodopsin subfamily of G-protein-coupled receptor (GPCR) family. OPRK1 is consist of 380 amino acids and is widely expressed in the nervous system. OPRK1 is activated by endogenous opioid peptide agonists derived from prodynorphin. Stimulation of OPRK1 in vivo produces many effects, including analgesia, water diuresis, dysphoria, antipruritic effects, and attenuation of cocaine craving in addicts. In addition, some studies reported that OPRK1 is associated with alcohol intake and the risk for alcohol dependence and activation of OPRK1 in human microglia suppresses HIV-1 expression.

Application

WB 5.0 μg/mL
IHC Not tested
ICC 1.0 μg/mL
ELISA Not tested
FCM 1.0 μg/mL
Neutralization Not tested
IP 5.0 μg/mL


Blue:DAPI
Green:KG139(2nd Ab :anti-mIgG FITC-conjugated)
Immunocytochemical staining of HEK293T cellsoverexpressing human KOR

Character

Primary Source HGNC: 8154
Type Monoclonal
Immunogen hKOR expressing cell line
Raised in Mouse
Myeloma P3U1
Clone number 5E3
Isotype IgG1 κ
Source Serum Free Medium
Purification notes ProteinG
Cross Reactivity Not yet tested in other species.
Concentration 0.25 mg/mL
Contents(Volume) 25 μg(100 μL/vial)
Label Unlabeled
Buffer PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Storage Store below 20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Simonin F. et al.: kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7006-10.
2. Chao CC. et al.: kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):8051-6.
3. Edenberg HJ. et al.: A regulatory variation in OPRK1, the gene encoding the kappa-opioid receptor, is associated with alcohol dependence. Hum Mol Genet. 2008 Jun 15;17(12):1783-9. Epub 2008 Mar 4
4. Simonin F. et al.: Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. EMBO J. 1998 Feb 16;17(4):886-97.

Product List

Product Name Cat# Quantity Price

Anti KOR

KAL-KG139 25UG

¥ 55,000
$ 734
€ 550