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Anti Siah2 Polyclonal Antibody

Background

The turnover of a protein is precisely under control in the cell. Particularly, the system of controlling protein degradation via the ubiquitin-proteosome pathway is involving in many kinds of process in the cell. The Drosophila Seven in absentina (Sina) gene product originally was identified as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah1 and Siah2, have been described that they might involve in ubiquitin-mediated proteolysis of several proteins, as well as in growth arrest and p53-induced apoptosis. Siah2 is expressed in olfactory epithelium, retina, forebrain and proliferating cartilage of developing bone by mRNA level.
This antibody is very useful for identifying the function of the mammalian Siah2 in the cell.

Package Size 25g (100L/vial)
Format Rabbit polyclonal antibody 0.25mg/mL
Buffer Block Ace as a stabilizer, containing 0.1%Proclin as bacteriostat
Storage Below 20°C
Once thawed, store at 4?. Repeated freeze-thaw cycles should be avoided.
This antibody was purified from rabbit serum by affinity chromatography.
Working dilution Western Blotting: 0.8g/mL

Western Blotting

Sample:293 cell lysate
1) control
2) Siah2 gene transgenic cell+MG-132 (protease inhibitor)

Preparation of antibodies and instruction
Dr.Koki Moriyoshi at Department of Biological Sciences, Kyoto University Faculty of Medicine

Product List

Product Name Cat# Quantity Price

Anti SIAH 2

KAL-KR056 25UG

¥ 49,000
$ 654
€ 490

Citation
  • Cancer Res. 2006 Oct 15;66(20):9870-7.

References
  • Development; 117, p1333-1343 (1993)
  • Genes Development; 11, p2701-2714 (1997)
  • Molecular Cell Biol.; 7, p915-926 (2001)
  • Molecular Cell Biol.; 7, p927-936 (2001)
  • Nature Struct. Biol.; 9, p68-75 (2002)

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.