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Anti Neuroglycan C (C1)

Background

Neuroglycan C (NGC/CALEB) is a transmembrane-type of chondroitin sulfate proteoglycan with a core glycoprotein of 120 kDa, and is exclusively expressed in the central nervous system. NGC expression is developmentally regulated, and is altered by addiction to psychostimulants as well as by nerve lesions. NGC is a novel part-time proteoglycan that changes its structure from a proteoglycan form to a non-proteoglycan form without chondroitin sulfate side chains during the development of the cerebellum and retina. NGC gene is a potential susceptibility gene for schizophrenia. This antibody recognizes effectively the core glycoprotein of NGC.

Application

  • Western blotting: 1/10,000 
  • Immunohistochemistry: 1/200 (Paraffin section), 1/500 - 1/1000 (Frozen section) 
  • Immunoprecipitaion: 1/500 

Other applications have not been tested. Optimal dilutions/concentrations should be determined by the end user.

Antibody Characterization

Characterization of the monoclonal anti-neuroglycan C antibody (clone C1) 
Immunoblotting using the anti-neuroglycan C antibody of a partially purified preparation of 
membrane-bound proteoglycans from brains of 10-day-old rats (lane 1), and that digested 
with chondroitinase ABC (CHase ABC; lane 2). 
Reference: J. Biol. Chem., 270 (1995) 26876-26882
Characterization of the monoclonal anti-neuroglycan C antibody (clone C1)
Immunoblotting using the anti-neuroglycan C antibody of a partially purified preparation of membrane-bound proteoglycans from brains of 10-day-old rats (lane 1), and that digested with chondroitinase ABC (CHase ABC; lane 2).
Reference: J. Biol. Chem., 270 (1995) 26876-26882

Product List

Product Name Cat# Quantity Price

Anti Neuroglycan C

CAC-NU-07-003 200UL

¥ 50,000
$ 667
€ 500

References
  •  Watanabe E. et al., Neuroglycan C, a novel membrane-spanning chondroitin sulfate proteoglycan that is restricted to the brain. J Biol Chem. 1995 Nov 10;270(45):26876-82. PMID: 7592931
  •  Shuo, T. et al, Glycoconj. J., 20, 257-278 (2004)
  •  Oohira, A., et al.: Glycoconj. J., 21, 53-57 (2004)
  •  Ichihara-Tanaka K. et al, Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells. J Biol Chem. 2006 Oct 13;281(41):30857-64. Epub 2006 Aug 10. PMID: 16901907

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.