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For research of oxidative stress! a1-antitrypsin,AAT,serine proteinase inhibitor,native AAT,ox-AAT

Anti Native & Oxidized α1 antitrypsin

Background

a1-antitrypsin(AAT) is one of the serine proteinase inhibitors that are present in human serum. In sera, AAT is present as native AAT, which inhibits serine proteinase and elastase-AAT complex and oxidized AAT(ox-AAT), which is oxidized by reactive oxygen species from activated neutrophils, resulting in a loss of activity.
It is considered that ox-AAT is a marker of oxidative stress and is related to pulmonary enphysema or COPD
The antibody (3F4) recognizes the ox-AAT, and S3-1 recognizes the native AAT.
These antibodies can be used for EIA, western blotting, immunohistochemical staining, and using this antibody, ox-AAT can be distinguished from native AAT.

<Reference>
1. Ueda M, Mashiba S, Uchida K. Evaluation of oxidized alpha-1-antitrypsin in blood as an oxidativestress marker using anti-oxidative a1-AT monoclonal antibody. Clinica Chimica Acta 2002; 317: 125-131.
2. Mashiba S, Wada Y, Takeya M, Sugiyama A, Hamakubo T, Nakamura A, Noguchi N, Niki E, Izumi A, Kobayashi M, Uchida K, Kodama T. In vivo complex formation of oxidized a1-antitrypsin and LDL. Arterioscler Thromb Vasc Biol 2001; 21: 1801-1808.

Product List

Product Name Cat# Quantity Price

Anti Native ALPHA1 Antitrypsin

IKG-KMSLS3-1 100UG

¥ 60,000
$ 800
€ 600

Anti Oxidized ALPHA1 Antitrypsin

IKG-KMSL3F4 100UG

¥ 60,000
$ 800
€ 600

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.