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Anti Mouse Trpm2 Polyclonal Antibody

Background

Function : Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity.
Tissue specificity : Widely expressed, with highest levels in lung, spleen, eye and brain.
Sequence similarities : Belongs to the transient receptor family. LTrpC subfamily. Contains 1 nudix hydrolase domain.

Application

Catalog number : KAL-KO462
ELISA WB IHC ICC
1.0 μg/mL Not tested Not tested 1.0-5.0 μg/mL
IP FCM IF Neutralization
Not tested Not tested Not tested Not tested
Catalog number : KAL-KO463
ELISA WB IHC ICC
1.0 μg/mL 1.0-5.0 μg/mL 5.0-10 μg/mL 1.0-5.0 μg/mL
IP FCM IF Neutralization
Not tested Not tested Not tested Not tested

Character

Type Polyclonal Antibody
Immunogen Partial peptide of Mouse Trpm2 middle region
Raised in Rabbit
Source Rabbit Serum
Purification notes Antigen Affinity
Cross Reactivity Human, Rat (KAL-KO463)
Concentration 0.25 mg/mL
Contents (Volume) 25 μg (100 μL/vial)
Label Unlabeled
Buffer PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]
Storage Store below -20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.

<Reference>
1. Kaneko S, et al. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci. 2006 May;101(1):66-76. *Application Reference
2. Hara Y, et al. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. 2002 Jan;9(1):163-73.
3. Togashi K, et al. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J. 2006 May 3;25(9):1804-15. *Application Reference
4. Yamamoto S, et al. TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med. 2008 Jul;14(7):738-47. *Application Reference

Product List

Product Name Cat# Quantity Price

Anti Trpm2

KAL-KO462 25UG

¥ 49,000
$ 654
€ 490

Anti Trpm2

KAL-KO463 25UG

¥ 49,000
$ 654
€ 490

To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.