Function : Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Tissue specificity : Lung and brain. Post-translational modification: N-glycosylated.
Sequence similarities : Belongs to the transient receptor family. STrpC subfamily. Contains 3 ANK repeats.
|1.0 μg/mL||Not tested||5.0-10 μg/mL||1.0-5.0 μg/mL|
|Not tested||Not tested||Not tested||Not tested|
|Immunogen||Partial peptide of Mouse Trpc6 C-terminal|
|Purification notes||Antigen Affinity|
|Concentration||0.25 mg / mL|
|Contents (Volume)||25 μg (100 μL / vial)|
|Buffer||PBS [containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat]|
|Storage||Store below -20 °C. Once thawed, store at 4 °C. Repeated freeze-thaw cycles should be avoided.|
1. Inoue R, et al. The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res. 2001 Feb 16;88(3):325-32. *Application Reference.
To be used for research only. DO NOT use for human gene therapy or clinical diagnosis.